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- W2307151993 abstract "Population stratification and differences in individuals’ ancestry can potentially bias genomewide genetic analyses when they are not detected and included in the genetic model. This is especially important in situation where little is known about the extent and sources of stratification. Here a large sample of tropically adapted cattle, Brahman (BB) and Tropical Composite (TC), genotyped for more than 700K SNP loci were evaluated for population stratification using principal components and supervised hierarchical clustering analyses. The BB cattle were more homogeneous than the TC cattle in both analyses, reflecting the TC’s more recent and complex origin. Nevertheless, within both breeds there were degrees of variability. The effect of farm of origin was also noticeable, particularly in TC. These analyses indicated that a simple breed designation, BB or TC, encompasses large variation in ancestry within breed. This opens the question whether ancestry composition should be included in downstream analyses. Appropriate use of information on ancestry composition could aid genome-wide association studies and genomic selection." @default.
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- W2307151993 date "2013-01-01" @default.
- W2307151993 modified "2023-10-05" @default.
- W2307151993 title "Population stratification and breed composition of Australian tropically adapted cattle." @default.
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