Matches in SemOpenAlex for { <https://semopenalex.org/work/W2307157071> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2307157071 endingPage "85.20" @default.
- W2307157071 startingPage "85.20" @default.
- W2307157071 abstract "Abstract Thpok is a zinc-finger (ZF) transcription factor essential for CD4 T cell development. Thpok promotes CD4 T helper lineage commitment, in part through the repression of genes necessary for CD8 differentiation. A member of the BTB-ZF subclass of ZF transcription factors, Thpok contains two conserved motifs: a carboxy-terminal ZF DNA binding domain, and an amino-terminal BTB motif. Although the BTB domain is required for Thpok to promote CD4 lineage differentiation, its contribution to Thpok function is not clear. In vitro analyses of the BTB domain of the prototype family member, Bcl6 (B cell lymphoma 6) revealed a role of the BTB domain in oligomerization and transcriptional repression. In the present study, we examined whether the Thpok BTB domain simply serves to promote dimerization of Thpok molecules, or whether it also serves to recruit other transcriptional regulators. We generated chimeric Thpok proteins by replacing the BTB domain of Thpok with that of other family members, or with a heterologous dimerization domain. All chimeric molecules containing the BTB domains tested blocked CD8 lineage specific gene expression; in contrast, the chimeric molecule carrying a heterologous dimerization domain was only partially functional. These results indicate that the BTB domain of Thpok not only promotes dimerization but it also serves to control transcription, presumably through interactions with transcriptional corepressors." @default.
- W2307157071 created "2016-06-24" @default.
- W2307157071 creator A5007275273 @default.
- W2307157071 creator A5039106046 @default.
- W2307157071 creator A5042053176 @default.
- W2307157071 creator A5059640675 @default.
- W2307157071 creator A5071263465 @default.
- W2307157071 date "2010-04-01" @default.
- W2307157071 modified "2023-10-16" @default.
- W2307157071 title "Two distinct functions for the BTB domain of the CD4-differentiating factor Thpok (85.20)" @default.
- W2307157071 doi "https://doi.org/10.4049/jimmunol.184.supp.85.20" @default.
- W2307157071 hasPublicationYear "2010" @default.
- W2307157071 type Work @default.
- W2307157071 sameAs 2307157071 @default.
- W2307157071 citedByCount "0" @default.
- W2307157071 crossrefType "journal-article" @default.
- W2307157071 hasAuthorship W2307157071A5007275273 @default.
- W2307157071 hasAuthorship W2307157071A5039106046 @default.
- W2307157071 hasAuthorship W2307157071A5042053176 @default.
- W2307157071 hasAuthorship W2307157071A5059640675 @default.
- W2307157071 hasAuthorship W2307157071A5071263465 @default.
- W2307157071 hasConcept C104317684 @default.
- W2307157071 hasConcept C123894998 @default.
- W2307157071 hasConcept C150194340 @default.
- W2307157071 hasConcept C153911025 @default.
- W2307157071 hasConcept C185592680 @default.
- W2307157071 hasConcept C186310378 @default.
- W2307157071 hasConcept C24284526 @default.
- W2307157071 hasConcept C40767141 @default.
- W2307157071 hasConcept C54355233 @default.
- W2307157071 hasConcept C86339819 @default.
- W2307157071 hasConcept C86803240 @default.
- W2307157071 hasConcept C95444343 @default.
- W2307157071 hasConceptScore W2307157071C104317684 @default.
- W2307157071 hasConceptScore W2307157071C123894998 @default.
- W2307157071 hasConceptScore W2307157071C150194340 @default.
- W2307157071 hasConceptScore W2307157071C153911025 @default.
- W2307157071 hasConceptScore W2307157071C185592680 @default.
- W2307157071 hasConceptScore W2307157071C186310378 @default.
- W2307157071 hasConceptScore W2307157071C24284526 @default.
- W2307157071 hasConceptScore W2307157071C40767141 @default.
- W2307157071 hasConceptScore W2307157071C54355233 @default.
- W2307157071 hasConceptScore W2307157071C86339819 @default.
- W2307157071 hasConceptScore W2307157071C86803240 @default.
- W2307157071 hasConceptScore W2307157071C95444343 @default.
- W2307157071 hasIssue "1_Supplement" @default.
- W2307157071 hasLocation W23071570711 @default.
- W2307157071 hasOpenAccess W2307157071 @default.
- W2307157071 hasPrimaryLocation W23071570711 @default.
- W2307157071 hasRelatedWork W1494918240 @default.
- W2307157071 hasRelatedWork W1974814963 @default.
- W2307157071 hasRelatedWork W1982598635 @default.
- W2307157071 hasRelatedWork W2034537363 @default.
- W2307157071 hasRelatedWork W2089990273 @default.
- W2307157071 hasRelatedWork W2102551026 @default.
- W2307157071 hasRelatedWork W2288366870 @default.
- W2307157071 hasRelatedWork W2367328247 @default.
- W2307157071 hasRelatedWork W3010488612 @default.
- W2307157071 hasRelatedWork W2181909253 @default.
- W2307157071 hasVolume "184" @default.
- W2307157071 isParatext "false" @default.
- W2307157071 isRetracted "false" @default.
- W2307157071 magId "2307157071" @default.
- W2307157071 workType "article" @default.