FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2307165722> ?p ?o ?g. }

• W2307165722 endingPage "7815" @default.
• W2307165722 startingPage "7801" @default.
• W2307165722 abstract "// Alena J. Smith 1, 2 , Yang-An Wen 1 , Payton D. Stevens 1, 2 , Jingpeng Liu 1 , Chi Wang 1 , Tianyan Gao 1, 2 1 Markey Cancer Center, University of Kentucky, Lexington, KY, USA 2 Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA Correspondence to: Tianyan Gao, e-mail: tianyan.gao@uky.edu Keywords: pancreatic cancer, cell migration, tumor suppressor, PHLPP, integrin Received: August 06, 2015     Accepted: January 01, 2016     Published: January 08, 2016 ABSTRACT Pancreatic adenocarcinoma is currently the fourth leading cause for cancer-related mortality. Malignant progression of pancreatic cancer depends not only on rapid proliferation of tumor cells but also on increased cell motility. In this study, we showed that increased PHLPP expression significantly reduced the rate of migration in pancreatic ductal adenocarcinoma (PDAC) cells whereas knockdown of PHLPP had the opposite effect. In addition, cell motility at the individual cell level was negatively regulated by PHLPP as determined using time-lapse imaging. Interestingly, the expression of β1 and β4 integrin proteins were decreased in PHLPP overexpressing cells and increased in PHLPP knockdown cells whereas the mRNA levels of integrin were not altered by changes in PHLPP expression. In determining the molecular mechanism underlying PHLPP-mediated regulation of integrin expression, we found that inhibition of lysosome activity rescued integrin expression in PHLPP overexpressing cells, thus suggesting that PHLPP negatively controls cell motility by inhibiting Akt activity to promote lysosome-dependent degradation of integrins. Functionally, the increased cell migration observed in PHLPP knockdown cells was effectively blocked by the neutralizing antibodies against β1 or β4 integrin. Taken together, our study identified a tumor suppressor role of PHLPP in suppressing cell motility by negatively regulating integrin expression in pancreatic cancer cells." @default.
• W2307165722 created "2016-06-24" @default.
• W2307165722 creator A5012607011 @default.
• W2307165722 creator A5048543466 @default.
• W2307165722 creator A5048724454 @default.
• W2307165722 creator A5075559574 @default.
• W2307165722 creator A5083222161 @default.
• W2307165722 creator A5086806378 @default.
• W2307165722 date "2016-01-08" @default.
• W2307165722 modified "2023-10-16" @default.
• W2307165722 title "PHLPP negatively regulates cell motility through inhibition of Akt activity and integrin expression in pancreatic cancer cells" @default.
• W2307165722 cites W1417555467 @default.
• W2307165722 cites W1482819678 @default.
• W2307165722 cites W1922475963 @default.
• W2307165722 cites W1923045889 @default.
• W2307165722 cites W1980039397 @default.
• W2307165722 cites W1984879511 @default.
• W2307165722 cites W1988852924 @default.
• W2307165722 cites W1997014592 @default.
• W2307165722 cites W1998778049 @default.
• W2307165722 cites W2011901667 @default.
• W2307165722 cites W2013466786 @default.
• W2307165722 cites W2021009075 @default.
• W2307165722 cites W2022491847 @default.
• W2307165722 cites W2022772242 @default.
• W2307165722 cites W2032116587 @default.
• W2307165722 cites W2037450317 @default.
• W2307165722 cites W2060021827 @default.
• W2307165722 cites W2062609674 @default.
• W2307165722 cites W2063790945 @default.
• W2307165722 cites W2068322045 @default.
• W2307165722 cites W2072278671 @default.
• W2307165722 cites W2087567111 @default.
• W2307165722 cites W2092528157 @default.
• W2307165722 cites W2095304369 @default.
• W2307165722 cites W2096961265 @default.
• W2307165722 cites W2107487363 @default.
• W2307165722 cites W2108132199 @default.
• W2307165722 cites W2116659145 @default.
• W2307165722 cites W2120528492 @default.
• W2307165722 cites W2121242600 @default.
• W2307165722 cites W2128204864 @default.
• W2307165722 cites W2140114244 @default.
• W2307165722 cites W2147000598 @default.
• W2307165722 cites W2151447617 @default.
• W2307165722 cites W2164985111 @default.
• W2307165722 cites W2166725434 @default.
• W2307165722 cites W2398619901 @default.
• W2307165722 cites W4211122150 @default.
• W2307165722 cites W4253861989 @default.
• W2307165722 doi "https://doi.org/10.18632/oncotarget.6848" @default.
• W2307165722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4884955" @default.
• W2307165722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26760962" @default.
• W2307165722 hasPublicationYear "2016" @default.
• W2307165722 type Work @default.
• W2307165722 sameAs 2307165722 @default.
• W2307165722 citedByCount "16" @default.
• W2307165722 countsByYear W23071657222016 @default.
• W2307165722 countsByYear W23071657222017 @default.
• W2307165722 countsByYear W23071657222018 @default.
• W2307165722 countsByYear W23071657222019 @default.
• W2307165722 countsByYear W23071657222020 @default.
• W2307165722 countsByYear W23071657222021 @default.
• W2307165722 countsByYear W23071657222022 @default.
• W2307165722 countsByYear W23071657222023 @default.
• W2307165722 crossrefType "journal-article" @default.
• W2307165722 hasAuthorship W2307165722A5012607011 @default.
• W2307165722 hasAuthorship W2307165722A5048543466 @default.
• W2307165722 hasAuthorship W2307165722A5048724454 @default.
• W2307165722 hasAuthorship W2307165722A5075559574 @default.
• W2307165722 hasAuthorship W2307165722A5083222161 @default.
• W2307165722 hasAuthorship W2307165722A5086806378 @default.
• W2307165722 hasBestOaLocation W23071657221 @default.
• W2307165722 hasConcept C121608353 @default.
• W2307165722 hasConcept C137738243 @default.
• W2307165722 hasConcept C1491633281 @default.
• W2307165722 hasConcept C173396325 @default.
• W2307165722 hasConcept C2780210213 @default.
• W2307165722 hasConcept C502942594 @default.
• W2307165722 hasConcept C54355233 @default.
• W2307165722 hasConcept C55493867 @default.
• W2307165722 hasConcept C62478195 @default.
• W2307165722 hasConcept C75217442 @default.
• W2307165722 hasConcept C81885089 @default.
• W2307165722 hasConcept C86554907 @default.
• W2307165722 hasConcept C86803240 @default.
• W2307165722 hasConcept C95444343 @default.
• W2307165722 hasConceptScore W2307165722C121608353 @default.
• W2307165722 hasConceptScore W2307165722C137738243 @default.
• W2307165722 hasConceptScore W2307165722C1491633281 @default.
• W2307165722 hasConceptScore W2307165722C173396325 @default.
• W2307165722 hasConceptScore W2307165722C2780210213 @default.
• W2307165722 hasConceptScore W2307165722C502942594 @default.
• W2307165722 hasConceptScore W2307165722C54355233 @default.
• W2307165722 hasConceptScore W2307165722C55493867 @default.
• W2307165722 hasConceptScore W2307165722C62478195 @default.
• W2307165722 hasConceptScore W2307165722C75217442 @default.
• W2307165722 hasConceptScore W2307165722C81885089 @default.

• next