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• W2307236318 abstract "Background: Porphyromonas gingivalis ( Pg ) is a major etiologic agent of periodontitis, whose virulence has been attributed to different factors, including lipopolysaccharide (LPS). Vascular ectopic calcification as a well‐known major risk factor for adverse cardiovascular diseases is a highly prevalent vascular pathophenotype, and vascular smooth muscle cells (VSMCs) play an important role in mediating vascular calcification. It was hypothesized that Pg ‐LPS may stimulate vascular calcification through a direct effect on VSMC function. To test this hypothesis, the effect of Pg ‐LPS on VSMC calcification was determined. Methods: Primary cultures of VSMCs were obtained and identified by immunochemistry in vitro. The proliferation and alkaline phosphatase (ALP) activity of VSMCs were measured using a cell counting kit and an ALP activity test. Mineral deposition was examined using alizarin red staining. Gene (e.g. ALP , core binding factor α1 [ Cbfα1 ], bone sialoprotein [ BSP ], and osteopontin [ OPN ]) expression levels altered by Pg ‐LPS were determined by reverse transcription‐polymerase chain reaction array. Results: Pg ‐LPS could increase the proliferation of VSMCs at different times and enhance ALP activity of VSMCs after 1 day. Alizarin red staining and quantification showed that, with Pg ‐LPS treatment, VSMCs displayed more obvious calcification nodules. When stimulated with Pg ‐LPS, the expression of specific osteogenic genes (e.g., ALP , Cbfα1 , BSP , and OPN ) was significantly promoted in the presence or absence of mineralization‐inducing medium, whereas the expression of the OPN gene was inhibited in the mineralization induction group at day 7. Conclusion: Pg ‐LPS can stimulate VSMC calcification, which results in vascular calcification, further proving the precise relationship between periodontitis and vascular calcification." @default.
• W2307236318 created "2016-06-24" @default.
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• W2307236318 date "2016-07-01" @default.
• W2307236318 modified "2023-09-23" @default.
• W2307236318 title "<i>Porphyromonas gingivalis</i>Lipopolysaccharide Stimulation of Vascular Smooth Muscle Cells Activates Proliferation and Calcification" @default.
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• W2307236318 doi "https://doi.org/10.1902/jop.2016.150602" @default.
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• W2307236318 hasPublicationYear "2016" @default.
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