FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2307264515> ?p ?o ?g. }

• W2307264515 endingPage "295" @default.
• W2307264515 startingPage "290" @default.
• W2307264515 abstract "Hyaluronan has diverse biological activities depending on its molecular size. The hyaluronan fragments (50 kDa) can decrease adipogenic differentiation in vitro. However, in vivo anti-obesitic effects of hyaluronan fragments have not been elucidated. Therefore, we examined the anti-obesity effects of hyaluronan fragments on high-fat diet induced obesity in C57BL/6 mice. Oral administration of hyaluronan fragments (200 mg/kg for 8 weeks) decreased body weight, adipose tissues, serum lipid (low-density lipoprotein cholesterol, triglyceride), and leptin level. Hyaluronan fragments decreased the hypertrophy of adipose tissue and ameliorated liver steatosis. The mRNA expression of leptin was reduced in adipocyte by treatment with hyaluronan fragments. Additionally, hyaluronan fragments enhanced the mRNA expression of PPAR-α and its target genes UCP-2 and decreased mRNA expression of PPAR- γ and fatty acid synthase in liver. In conclusions, hyaluronan fragments had marked effects on inhibiting the development of obesity in obese mice fed the high-fat diet. It suggested that enhancing PPAR-α and suppressing PPAR-γ expression are two possible mechanisms for the anti-obesitic effect of hyaluronan fragments." @default.
• W2307264515 created "2016-06-24" @default.
• W2307264515 creator A5010553661 @default.
• W2307264515 creator A5035139148 @default.
• W2307264515 creator A5040314447 @default.
• W2307264515 creator A5082673485 @default.
• W2307264515 creator A5087894765 @default.
• W2307264515 date "2016-04-01" @default.
• W2307264515 modified "2023-10-04" @default.
• W2307264515 title "Anti-obesity potential of enzymatic fragments of hyaluronan on high-fat diet-induced obesity in C57BL/6 mice" @default.
• W2307264515 cites W1579033090 @default.
• W2307264515 cites W1794039655 @default.
• W2307264515 cites W1974209694 @default.
• W2307264515 cites W1974744093 @default.
• W2307264515 cites W1985076741 @default.
• W2307264515 cites W1988112870 @default.
• W2307264515 cites W1994014704 @default.
• W2307264515 cites W2000223380 @default.
• W2307264515 cites W2002149738 @default.
• W2307264515 cites W2036139926 @default.
• W2307264515 cites W2036747551 @default.
• W2307264515 cites W2040588495 @default.
• W2307264515 cites W2043423139 @default.
• W2307264515 cites W2045813821 @default.
• W2307264515 cites W2061288331 @default.
• W2307264515 cites W2095486779 @default.
• W2307264515 cites W2097544331 @default.
• W2307264515 cites W2102313291 @default.
• W2307264515 cites W2106828230 @default.
• W2307264515 cites W2138110569 @default.
• W2307264515 cites W2139966914 @default.
• W2307264515 cites W2145188367 @default.
• W2307264515 cites W2160235960 @default.
• W2307264515 cites W2163710303 @default.
• W2307264515 cites W2165343591 @default.
• W2307264515 cites W2173681478 @default.
• W2307264515 cites W2186925492 @default.
• W2307264515 cites W2202603469 @default.
• W2307264515 doi "https://doi.org/10.1016/j.bbrc.2016.03.098" @default.
• W2307264515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27012203" @default.
• W2307264515 hasPublicationYear "2016" @default.
• W2307264515 type Work @default.
• W2307264515 sameAs 2307264515 @default.
• W2307264515 citedByCount "11" @default.
• W2307264515 countsByYear W23072645152017 @default.
• W2307264515 countsByYear W23072645152018 @default.
• W2307264515 countsByYear W23072645152019 @default.
• W2307264515 countsByYear W23072645152020 @default.
• W2307264515 countsByYear W23072645152022 @default.
• W2307264515 countsByYear W23072645152023 @default.
• W2307264515 crossrefType "journal-article" @default.
• W2307264515 hasAuthorship W2307264515A5010553661 @default.
• W2307264515 hasAuthorship W2307264515A5035139148 @default.
• W2307264515 hasAuthorship W2307264515A5040314447 @default.
• W2307264515 hasAuthorship W2307264515A5082673485 @default.
• W2307264515 hasAuthorship W2307264515A5087894765 @default.
• W2307264515 hasConcept C122927707 @default.
• W2307264515 hasConcept C126322002 @default.
• W2307264515 hasConcept C134018914 @default.
• W2307264515 hasConcept C150903083 @default.
• W2307264515 hasConcept C171089720 @default.
• W2307264515 hasConcept C185592680 @default.
• W2307264515 hasConcept C207001950 @default.
• W2307264515 hasConcept C2776175234 @default.
• W2307264515 hasConcept C2776175330 @default.
• W2307264515 hasConcept C2777529286 @default.
• W2307264515 hasConcept C2778163477 @default.
• W2307264515 hasConcept C2778772119 @default.
• W2307264515 hasConcept C2778913445 @default.
• W2307264515 hasConcept C2779134260 @default.
• W2307264515 hasConcept C2780613262 @default.
• W2307264515 hasConcept C511355011 @default.
• W2307264515 hasConcept C54355233 @default.
• W2307264515 hasConcept C71924100 @default.
• W2307264515 hasConcept C86803240 @default.
• W2307264515 hasConceptScore W2307264515C122927707 @default.
• W2307264515 hasConceptScore W2307264515C126322002 @default.
• W2307264515 hasConceptScore W2307264515C134018914 @default.
• W2307264515 hasConceptScore W2307264515C150903083 @default.
• W2307264515 hasConceptScore W2307264515C171089720 @default.
• W2307264515 hasConceptScore W2307264515C185592680 @default.
• W2307264515 hasConceptScore W2307264515C207001950 @default.
• W2307264515 hasConceptScore W2307264515C2776175234 @default.
• W2307264515 hasConceptScore W2307264515C2776175330 @default.
• W2307264515 hasConceptScore W2307264515C2777529286 @default.
• W2307264515 hasConceptScore W2307264515C2778163477 @default.
• W2307264515 hasConceptScore W2307264515C2778772119 @default.
• W2307264515 hasConceptScore W2307264515C2778913445 @default.
• W2307264515 hasConceptScore W2307264515C2779134260 @default.
• W2307264515 hasConceptScore W2307264515C2780613262 @default.
• W2307264515 hasConceptScore W2307264515C511355011 @default.
• W2307264515 hasConceptScore W2307264515C54355233 @default.
• W2307264515 hasConceptScore W2307264515C71924100 @default.
• W2307264515 hasConceptScore W2307264515C86803240 @default.
• W2307264515 hasFunder F4320334880 @default.
• W2307264515 hasIssue "1" @default.
• W2307264515 hasLocation W23072645151 @default.
• W2307264515 hasLocation W23072645152 @default.

• next