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• W2307368712 abstract "Abstract Background Non‐immediate reactions to beta‐lactam antibiotics ( BL ) occur more than one hour after drug administration, and the most common manifestations are maculopapular exanthemas and delayed‐appearing urticaria and/or angioedema. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions ( DHR ), if a drug is taken at the same time. The most of children are labeled as ‘drug allergic’ after considering only the clinical history. Objective To diagnose/detect a hypersensitivity or an infection which mimic DHR in children with non‐immediate reactions to BL Methods A prospective survey was conducted in a group of 1026 children with histories of non‐immediate reactions to BL by performing patch tests, skin tests, and in case of negative results, drug provocation tests ( DPT s). In 300 children, a study was performed to detect infections by viruses or Mycoplasma pneumoniae. Results Urticaria and maculopapular exanthemas were the most reported non‐immediate reactions. Only 76 (7.4%) of 1026 children had confirmed non‐immediate hypersensitivity reactions to BL . Fifty‐seven children had positive delayed‐reading intradermal tests (18 of these with a positive patch test). Nineteen children had positive DPT . Sixty‐six of 300 children had positive tests for viruses or Mycoplasma pneumoniae and 2 of them had a positive allergy work‐up. Conclusions A diagnostic work‐up should be performed in all children with non‐immediate reactions to BL , to remove a false label of hypersensitivity. Even though only 57 (5.5%) of 1026 children displayed positive responses to delayed‐reading intradermal tests to BL , such tests appear to be useful in order to reduce the risk for positive DPT s." @default.
• W2307368712 created "2016-06-24" @default.
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• W2307368712 date "2016-05-06" @default.
• W2307368712 modified "2023-10-16" @default.
• W2307368712 title "Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up" @default.
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• W2307368712 doi "https://doi.org/10.1111/pai.12565" @default.
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