Matches in SemOpenAlex for { <https://semopenalex.org/work/W2307369805> ?p ?o ?g. }
- W2307369805 endingPage "77" @default.
- W2307369805 startingPage "66" @default.
- W2307369805 abstract "Low-grade chronic inflammation underlies the development of the most dangerous cardiometabolic disorders including type 2 diabetes and its vascular complications. In contrast to acute inflammation induced by bacteria and viruses, chronic inflammation can be driven by abnormal reaction to endogenous factors, including Th2 cytokines, metabolic factors like advanced glycation end products (AGEs), modified lipoproteins, or hyperglycemia. The key innate immune cells that recognize these factors in blood circulation are monocytes. Inflammatory programming of monocytes which migrate into tissues can, in turn, result into generation of tissue macrophages with pathological functions. Therefore, determination of the molecular and functional phenotype of circulating monocytes is a very promising diagnostic tool for the identification of hidden inflammation, which can precede the development of the pathology. Here we propose a new test system for the identification of inflammatory programming of monocytes: surface biomarkers and ex vivo functional system. We summarize the current knowledge about surface biomarkers for monocyte subsets, including CD16, CCR2, CX3CR1, CD64, stabilin-1 and CD36, and their association with inflammatory human disorders. Furthermore, we present the design of an ex vivo monocyte-based test system with minimal set of parameters as a potential diagnostic tool for the identification of personalized inflammatory responses." @default.
- W2307369805 created "2016-06-24" @default.
- W2307369805 creator A5011305509 @default.
- W2307369805 creator A5011643232 @default.
- W2307369805 creator A5013460701 @default.
- W2307369805 creator A5058497078 @default.
- W2307369805 creator A5058678642 @default.
- W2307369805 date "2016-01-01" @default.
- W2307369805 modified "2023-10-18" @default.
- W2307369805 title "Perspectives for Monocyte/Macrophage-Based Diagnostics of Chronic Inflammation" @default.
- W2307369805 cites W1461572389 @default.
- W2307369805 cites W1561093084 @default.
- W2307369805 cites W1579115151 @default.
- W2307369805 cites W1589544688 @default.
- W2307369805 cites W1600410050 @default.
- W2307369805 cites W1668040492 @default.
- W2307369805 cites W1668669109 @default.
- W2307369805 cites W1768099775 @default.
- W2307369805 cites W1806387945 @default.
- W2307369805 cites W1840986526 @default.
- W2307369805 cites W1854150933 @default.
- W2307369805 cites W1902156119 @default.
- W2307369805 cites W1950723885 @default.
- W2307369805 cites W1964064254 @default.
- W2307369805 cites W1966720891 @default.
- W2307369805 cites W1970398937 @default.
- W2307369805 cites W1971344807 @default.
- W2307369805 cites W1973165168 @default.
- W2307369805 cites W1975451889 @default.
- W2307369805 cites W1975495740 @default.
- W2307369805 cites W1978566844 @default.
- W2307369805 cites W1982167473 @default.
- W2307369805 cites W1990444531 @default.
- W2307369805 cites W1991026693 @default.
- W2307369805 cites W1995063875 @default.
- W2307369805 cites W1995566485 @default.
- W2307369805 cites W1996823556 @default.
- W2307369805 cites W1997810606 @default.
- W2307369805 cites W1999463964 @default.
- W2307369805 cites W2002812554 @default.
- W2307369805 cites W2003176514 @default.
- W2307369805 cites W2012747049 @default.
- W2307369805 cites W2013104528 @default.
- W2307369805 cites W2015141049 @default.
- W2307369805 cites W2016251536 @default.
- W2307369805 cites W2017619851 @default.
- W2307369805 cites W2024884447 @default.
- W2307369805 cites W2027839715 @default.
- W2307369805 cites W2031010749 @default.
- W2307369805 cites W2031526332 @default.
- W2307369805 cites W2032896509 @default.
- W2307369805 cites W2033334568 @default.
- W2307369805 cites W2033531979 @default.
- W2307369805 cites W2035619549 @default.
- W2307369805 cites W2036087229 @default.
- W2307369805 cites W2037862168 @default.
- W2307369805 cites W2043610475 @default.
- W2307369805 cites W2045772297 @default.
- W2307369805 cites W2045796965 @default.
- W2307369805 cites W2050520863 @default.
- W2307369805 cites W2051484406 @default.
- W2307369805 cites W2052883386 @default.
- W2307369805 cites W2054753294 @default.
- W2307369805 cites W2054849090 @default.
- W2307369805 cites W2057096661 @default.
- W2307369805 cites W2057567899 @default.
- W2307369805 cites W2058631111 @default.
- W2307369805 cites W2062136940 @default.
- W2307369805 cites W2062756785 @default.
- W2307369805 cites W2063398521 @default.
- W2307369805 cites W2063627505 @default.
- W2307369805 cites W2065210647 @default.
- W2307369805 cites W2065746709 @default.
- W2307369805 cites W2065821720 @default.
- W2307369805 cites W2077881807 @default.
- W2307369805 cites W2078845812 @default.
- W2307369805 cites W2079170183 @default.
- W2307369805 cites W2084341978 @default.
- W2307369805 cites W2090136216 @default.
- W2307369805 cites W2090919511 @default.
- W2307369805 cites W2091844375 @default.
- W2307369805 cites W2092259937 @default.
- W2307369805 cites W2093151008 @default.
- W2307369805 cites W2094130843 @default.
- W2307369805 cites W2094951310 @default.
- W2307369805 cites W2100571347 @default.
- W2307369805 cites W2101415872 @default.
- W2307369805 cites W2102558296 @default.
- W2307369805 cites W2104935570 @default.
- W2307369805 cites W2108979835 @default.
- W2307369805 cites W2110038966 @default.
- W2307369805 cites W2110780943 @default.
- W2307369805 cites W2113474226 @default.
- W2307369805 cites W2113934014 @default.
- W2307369805 cites W2116422482 @default.
- W2307369805 cites W2118968734 @default.
- W2307369805 cites W2119261483 @default.
- W2307369805 cites W2120882909 @default.