Matches in SemOpenAlex for { <https://semopenalex.org/work/W2307384627> ?p ?o ?g. }
- W2307384627 endingPage "1382" @default.
- W2307384627 startingPage "1367" @default.
- W2307384627 abstract "The parathyroid hormone 1 receptor (PTHR) is central to the process of bone formation and remodeling. PTHR signaling requires receptor internalization into endosomes, which is then terminated by recycling or degradation. Here we show that sorting nexin 27 (SNX27) functions as an adaptor that couples PTHR to the retromer trafficking complex. SNX27 binds directly to the C-terminal PDZ-binding motif of PTHR, wiring it to retromer for endosomal sorting. The structure of SNX27 bound to the PTHR motif reveals a high-affinity interface involving conserved electrostatic interactions. Mechanistically, depletion of SNX27 or retromer augments intracellular PTHR signaling in endosomes. Osteoblasts genetically lacking SNX27 show similar disruptions in PTHR signaling and greatly reduced capacity for bone mineralization, contributing to profound skeletal deficits in SNX27-knockout mice. Taken together, our data support a critical role for SNX27-retromer mediated transport of PTHR in normal bone development." @default.
- W2307384627 created "2016-06-24" @default.
- W2307384627 creator A5001840642 @default.
- W2307384627 creator A5021945375 @default.
- W2307384627 creator A5031613802 @default.
- W2307384627 creator A5036906421 @default.
- W2307384627 creator A5051828242 @default.
- W2307384627 creator A5056823136 @default.
- W2307384627 creator A5065010407 @default.
- W2307384627 creator A5069457660 @default.
- W2307384627 creator A5079819010 @default.
- W2307384627 creator A5081859721 @default.
- W2307384627 creator A5084146581 @default.
- W2307384627 creator A5085078308 @default.
- W2307384627 date "2016-04-15" @default.
- W2307384627 modified "2023-09-29" @default.
- W2307384627 title "Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth" @default.
- W2307384627 cites W1604209299 @default.
- W2307384627 cites W191290535 @default.
- W2307384627 cites W1966311581 @default.
- W2307384627 cites W1968578345 @default.
- W2307384627 cites W1969840664 @default.
- W2307384627 cites W1980269923 @default.
- W2307384627 cites W1980310228 @default.
- W2307384627 cites W1980602971 @default.
- W2307384627 cites W1983044117 @default.
- W2307384627 cites W1986177696 @default.
- W2307384627 cites W1991466748 @default.
- W2307384627 cites W1991581759 @default.
- W2307384627 cites W1992576843 @default.
- W2307384627 cites W1993798820 @default.
- W2307384627 cites W1994287472 @default.
- W2307384627 cites W1994430971 @default.
- W2307384627 cites W1994824150 @default.
- W2307384627 cites W1995411796 @default.
- W2307384627 cites W1996836065 @default.
- W2307384627 cites W1998544686 @default.
- W2307384627 cites W1999151951 @default.
- W2307384627 cites W2003443990 @default.
- W2307384627 cites W2005284789 @default.
- W2307384627 cites W2005794914 @default.
- W2307384627 cites W2011520932 @default.
- W2307384627 cites W2014047760 @default.
- W2307384627 cites W2029190746 @default.
- W2307384627 cites W2029311635 @default.
- W2307384627 cites W2030980036 @default.
- W2307384627 cites W2031000099 @default.
- W2307384627 cites W2034171109 @default.
- W2307384627 cites W2034919163 @default.
- W2307384627 cites W2035268716 @default.
- W2307384627 cites W2036683613 @default.
- W2307384627 cites W2041342251 @default.
- W2307384627 cites W2042932723 @default.
- W2307384627 cites W2049746112 @default.
- W2307384627 cites W2053476250 @default.
- W2307384627 cites W2055349132 @default.
- W2307384627 cites W2058838325 @default.
- W2307384627 cites W2061111237 @default.
- W2307384627 cites W2062207135 @default.
- W2307384627 cites W2063690790 @default.
- W2307384627 cites W2064862804 @default.
- W2307384627 cites W2067080420 @default.
- W2307384627 cites W2073914665 @default.
- W2307384627 cites W2074854626 @default.
- W2307384627 cites W2079340565 @default.
- W2307384627 cites W2082289623 @default.
- W2307384627 cites W2082817154 @default.
- W2307384627 cites W2083829293 @default.
- W2307384627 cites W2087178496 @default.
- W2307384627 cites W2087336695 @default.
- W2307384627 cites W2087549132 @default.
- W2307384627 cites W2092482155 @default.
- W2307384627 cites W2098723659 @default.
- W2307384627 cites W2099764754 @default.
- W2307384627 cites W2100454832 @default.
- W2307384627 cites W2100503761 @default.
- W2307384627 cites W2115040576 @default.
- W2307384627 cites W2116002414 @default.
- W2307384627 cites W2122553885 @default.
- W2307384627 cites W2123160213 @default.
- W2307384627 cites W2124026197 @default.
- W2307384627 cites W2129699893 @default.
- W2307384627 cites W2135087298 @default.
- W2307384627 cites W2139286816 @default.
- W2307384627 cites W2141859364 @default.
- W2307384627 cites W2142227400 @default.
- W2307384627 cites W2150666277 @default.
- W2307384627 cites W2154945604 @default.
- W2307384627 cites W2156374977 @default.
- W2307384627 cites W2156556961 @default.
- W2307384627 cites W2156674480 @default.
- W2307384627 cites W2157559409 @default.
- W2307384627 cites W2158973504 @default.
- W2307384627 cites W2162353145 @default.
- W2307384627 cites W2163047938 @default.
- W2307384627 cites W2163341755 @default.
- W2307384627 cites W2166522627 @default.
- W2307384627 cites W2166569849 @default.