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- W2307442092 abstract "We report on a 90-year-old male patient with a <i>ROS1</i>-translocated adenocarcinoma of the lung who was treated with crizotinib as first-line therapy. After 11 months of treatment, we noticed complete metabolic response as measured by <sup>18</sup>F-FDG-PET/CT scan and a partial response according to RECIST criteria. This patient indicates that <i>ROS1</i> translocations are not restricted to young age, female gender and low stage. Furthermore, this case illustrates exemplarily that crizotinib therapy is effective and manageable even as first-line treatment in elderly patients with comorbidities. Based on our findings, we recommend to include elderly patients with advanced pulmonary adenocarcinomas in molecular screening approaches for <i>ROS1</i> translocations." @default.
- W2307442092 created "2016-06-24" @default.
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- W2307442092 date "2016-03-10" @default.
- W2307442092 modified "2023-10-18" @default.
- W2307442092 title "Partial Response to First-Line Crizotinib in an Elderly Male Patient with ROS1 Translocation-Positive Lung Cancer" @default.
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- W2307442092 doi "https://doi.org/10.1159/000444745" @default.
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