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- W2307471243 endingPage "554" @default.
- W2307471243 startingPage "527" @default.
- W2307471243 abstract "Mechanical force modulates development, influences tissue homeostasis, and contributes to disease. Forces sculpt tissue-level behaviors and direct cell fate by engaging mechanoreceptors and by altering organization of the cytoskeleton and actomyosin contractility to stimulate mechanotransduction mechanisms that alter transcription. Nevertheless, how force specifically leverages mechanotransduction pathways to control transcriptional regulation of cell fate remains unclear. Here we review recent findings specifically in the context of epithelial-to-mesenchymal transitions that have revealed conserved mechanisms whereby extracellular force, mediated through cell–extracellular matrix and cell-cell junctional complexes, induces transcriptional reprogramming to alter cell and tissue fate. We focus on the interplay between tissue mechanics and the epithelial-to-mesenchymal transitions that occur during embryonic development and cancer malignancy. We describe the adhesion-linked cellular machinery that mediates mechano-transduction and elaborate on how these force-linked networks stimulate key transcriptional programs that induce an epithelial-to-mesenchymal phenotypic transition, thereby providing an overview of how mechanical signals can be translated into a change in cell fate." @default.
- W2307471243 created "2016-06-24" @default.
- W2307471243 creator A5007180526 @default.
- W2307471243 creator A5020032355 @default.
- W2307471243 creator A5089067802 @default.
- W2307471243 date "2016-10-06" @default.
- W2307471243 modified "2023-09-25" @default.
- W2307471243 title "Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and Cancer" @default.
- W2307471243 cites W137372458 @default.
- W2307471243 cites W1517441438 @default.
- W2307471243 cites W1606615500 @default.
- W2307471243 cites W1750702309 @default.
- W2307471243 cites W1760215417 @default.
- W2307471243 cites W1782202106 @default.
- W2307471243 cites W1873165927 @default.
- W2307471243 cites W1886443720 @default.
- W2307471243 cites W1921522108 @default.
- W2307471243 cites W1945131110 @default.
- W2307471243 cites W1964847767 @default.
- W2307471243 cites W1971060242 @default.
- W2307471243 cites W1972338770 @default.
- W2307471243 cites W1976324983 @default.
- W2307471243 cites W1976719040 @default.
- W2307471243 cites W1977075884 @default.
- W2307471243 cites W1979988883 @default.
- W2307471243 cites W1980790180 @default.
- W2307471243 cites W1981562838 @default.
- W2307471243 cites W1982244057 @default.
- W2307471243 cites W1982280065 @default.
- W2307471243 cites W1982498121 @default.
- W2307471243 cites W1983991097 @default.
- W2307471243 cites W1984086927 @default.
- W2307471243 cites W1986199664 @default.
- W2307471243 cites W1992044002 @default.
- W2307471243 cites W1993006648 @default.
- W2307471243 cites W1994242450 @default.
- W2307471243 cites W1995592152 @default.
- W2307471243 cites W1996118868 @default.
- W2307471243 cites W1996566006 @default.
- W2307471243 cites W1997580253 @default.
- W2307471243 cites W1998975199 @default.
- W2307471243 cites W1999765951 @default.
- W2307471243 cites W2000982151 @default.
- W2307471243 cites W2001992345 @default.
- W2307471243 cites W2004754771 @default.
- W2307471243 cites W2005894439 @default.
- W2307471243 cites W2006300538 @default.
- W2307471243 cites W2008324315 @default.
- W2307471243 cites W2010638326 @default.
- W2307471243 cites W2011346718 @default.
- W2307471243 cites W2012095617 @default.
- W2307471243 cites W2015989042 @default.
- W2307471243 cites W2017341363 @default.
- W2307471243 cites W2019624372 @default.
- W2307471243 cites W2021597202 @default.
- W2307471243 cites W2022896763 @default.
- W2307471243 cites W2023026872 @default.
- W2307471243 cites W2023687572 @default.
- W2307471243 cites W2023922465 @default.
- W2307471243 cites W2024315189 @default.
- W2307471243 cites W2024997708 @default.
- W2307471243 cites W2025091374 @default.
- W2307471243 cites W2026652581 @default.
- W2307471243 cites W2027497744 @default.
- W2307471243 cites W2027810531 @default.
- W2307471243 cites W2029848748 @default.
- W2307471243 cites W2030194693 @default.
- W2307471243 cites W2031229219 @default.
- W2307471243 cites W2032718477 @default.
- W2307471243 cites W2033962173 @default.
- W2307471243 cites W2034792192 @default.
- W2307471243 cites W2035082502 @default.
- W2307471243 cites W2038569449 @default.
- W2307471243 cites W2040210675 @default.
- W2307471243 cites W2040916665 @default.
- W2307471243 cites W2040942754 @default.
- W2307471243 cites W2041012485 @default.
- W2307471243 cites W2042936107 @default.
- W2307471243 cites W2045100170 @default.
- W2307471243 cites W2045394733 @default.
- W2307471243 cites W2046679772 @default.
- W2307471243 cites W2047392037 @default.
- W2307471243 cites W2047529648 @default.
- W2307471243 cites W2049717739 @default.
- W2307471243 cites W2049718632 @default.
- W2307471243 cites W2051816002 @default.
- W2307471243 cites W2054541267 @default.
- W2307471243 cites W2055334948 @default.
- W2307471243 cites W2056360941 @default.
- W2307471243 cites W2057190824 @default.
- W2307471243 cites W2059372860 @default.
- W2307471243 cites W2060126259 @default.
- W2307471243 cites W2061600983 @default.
- W2307471243 cites W2062268212 @default.
- W2307471243 cites W2064644124 @default.
- W2307471243 cites W2065123583 @default.
- W2307471243 cites W2065179220 @default.
- W2307471243 cites W2066827957 @default.