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- W2307608625 abstract "// Su-Jin Baek 1, 2 , Mirang Kim 1, 3 , Dong-Hyuck Bae 1, 3 , Jeong-Hwan Kim 3 , Hee-Jin Kim 1, 3 , Myoung-Eun Han 4 , Sae-Ock Oh 4 , Yong Sung Kim 1, 3 , Seon-Young Kim 1, 2 1 Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea 2 Genomic Structure Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea 3 Epigenome Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea 4 Departments of Anatomy and Surgery, School of Medicine, Pusan National University, Busan, Republic of Korea Correspondence to: Seon-Young Kim, email: kimsy@kribb.re.kr Keywords: gastric cancer, DNA methylation, enhancer, promoter, lncRNAs Received: December 02, 2015 Accepted: March 10, 2016 Published: March 21, 2016 ABSTRACT Abnormal DNA methylation is an epigenetic mechanism that promotes gastric carcinogenesis. While the abnormal methylation at promoter regions has been characterized for many genes, the function of DNA methylation marks at distal regulatory regions in gastric cancer remains poorly described. Here, we performed RNA-seq, MBD-seq, and H3K27ac ChIP-seq on gastric tissues and cell lines to understand the epigenetic changes in the distal as well as the proximal regulatory regions. In total, 257,651 significant DMRs (Differentially methylated regions) were identified in gastric cancer, and the majority of these DMRs were located in the intergenic, intronic, and non-coding RNA regions. We identified the aberrant expression of many genes and lncRNAs due to changes in DNA methylation. Furthermore, we profiled the molecular subtype-specific methylation patterns in gastric cancer to characterize subtype-specific regulators that undergo DNA methylation changes. Our findings provide insights for understanding methylation changes at distal regulatory regions and reveal novel epigenetic targets in gastric cancer." @default.
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- W2307608625 date "2016-03-21" @default.
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- W2307608625 title "Integrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer" @default.
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- W2307608625 doi "https://doi.org/10.18632/oncotarget.8239" @default.
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