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- W2307672784 abstract "Objective To explore the effects and mechanisms of polydatin on rats with brain hemorrhagic injury.Methods The cerebral hemorrhage model in rats was induced by local injection of type Ⅶ collagenase and they were randomly divided into six groups.The treated groups were treated with polydatin and Naoxuekang;The normal and control groups were only treated with water.The changes of neurological defect were observed.The activity of SOD,the content of MDA,the protein expressions of Bcl-2 in brain tissue,and the contents of IL-1β in serum were measured.Results Compared with the cerebral hemorrhage model group,polydatin(25,50,and 100 mg/kg) could significantly reduce the symptoms of neurological deficits of cerebral hemorrhage rats,raise the activity of SOD,reduce the content of MDA,increase the protein expressions of Bcl-2,and decrease the contents of IL-1β in serum.Its effects were positively correlated with the dose-effect.Conclusion Polydatin has therapeutic effect on rats of cerebral hemorrhage,through against free radical damage and inhibiting neuronal apoptosis and inflammatory." @default.
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- W2307672784 date "2010-01-01" @default.
- W2307672784 modified "2023-09-27" @default.
- W2307672784 title "Effect of polydatin on IL-1β in serum and protein expression of Bcl-2 in brain tissue of cerebral hemorrhage injured rats." @default.
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