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• W2307694144 abstract "The molecular nature of signaling centers (organizers) plays a pivotal role in the formation of body axes in multicellular animals. Organizers secrete growth factors which act as long range regulators in axis formation and cell differentiation. To analyze the evolutionary origin of organizers, we studied Wnt and TGFs/Bmp signaling pathways in Hydra, a member of the primitive animal phylum Cnidaria. Molecules of the Wnt pathway and the TGFs/Bmp antagonist Chordin are expressed in the Hydra head organizer. They are transcriptionally upregulated early during asexual bud formation and head regeneration, and also define head organizers created by de novo pattern formation in aggregates. Thus, the Hydra head organizer exhibits astonishing similarities to organizers in vertebrates. Our results suggest that Wnt and TGFs/Bmp signaling is involved in axis formation in Hydra, and support the idea that these signalling pathways played a key role in the evolution of axial differentiation in the earliest multicellular animals." @default.
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• W2307694144 date "2007-05-15" @default.
• W2307694144 modified "2023-09-26" @default.
• W2307694144 title "SIGNALING MOLECULES IN THE HYDRA HEAD ORGANIZER AND THE EVOLUTION OF AXIS FORMATION" @default.
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• W2307694144 hasPublicationYear "2007" @default.
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