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- W2307820987 abstract "1889 Objectives We further investigated whether 131I-SPECT/CT may contribute to DTC current diagnosis and therapeutic post-operative protocol reassessment. Methods We enrolled 582 thyroidectomized DTC pts, 143 classified at high risk (H), 439 at low risk (L), 211 of whom at very low risk (VL), 14 observed after thyroidectomy before radioiodine therapy and 568 in follow-up; 526/582 pts underwent diagnostic and 56/582 post-therapeutic 131I-scintigraphy, with total 669 exams. Whole body scanning was followed by SPECT/CT in the neck and chest and other suspect regions using two dual head gamma cameras (Millennium VG and Infinia Hawkeye; GE Medical System) including low dose x-ray tubes. Results In 196/582 pts SPECT/CT identified 430 iodine fixing foci, 320 in the neck and 110 outside the neck. Planar in 146 pts evidenced 312 foci, 245 in the neck and 67 outside the neck, all positive at SPECT/CT. SPECT/CT evidenced, in 59 pts, 118 foci occult at planar, which was completely negative in 35/59 cases, with 83/118 foci being malignant. Globally, SPECT/CT ascertained 138 neoplastic lesions in 430 iodine foci, while planar 55, 25 of which unclear only characterized by SPECT/CT. Only SPECT/CT evidenced 7 neck lymph node metastases in 3L and 3VL pts and small size bone metastases in 2H cases with undetectable TG serum levels as well as 6 neck lymph node metastases in 6 pts (4H, 1L, 1VL) and pulmonary small size metastases in 1L and 1H cases with TG levels Conclusions SPECT/CT proved a reliable diagnostic tool in our DTC pts, particularly when whole body scan is inconclusive and TG levels are undetectable or very low and in L or VL cases. SPECT/CT correctly modified planar classification permitting more appropriate therapeutic strategies. Thus, the procedure can contribute to reassess DTC current management protocol and its wider use is suggested." @default.
- W2307820987 created "2016-06-24" @default.
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- W2307820987 date "2013-05-01" @default.
- W2307820987 modified "2023-09-26" @default.
- W2307820987 title "131I-SPECT/CT in differentiated thyroid carcinoma (DTC)" @default.
- W2307820987 hasPublicationYear "2013" @default.
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