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- W2307870967 abstract "Purpose To use quantitative susceptibility mapping (QSM) to investigate changes in cartilage canals in the distal femur of juvenile goats after their surgical transection. Methods Chondronecrosis was surgically induced in the right medial femoral condyles of four 4‐day‐old goats. Both the operated and control knees were harvested at 2, 3, 5, and 10 weeks after the surgeries. Ex vivo MRI scans were conducted at 9.4 Tesla using T RAFF (relaxation time along a fictitious field)‐weighted fast spin echo imaging and QSM to detect areas of chondronecrosis and investigate cartilage canal abnormalities. Histological sections from these same areas stained with hematoxylin and eosin and safranin O were evaluated to assess the affected tissues. Results Both the histological sections and the T RAFF ‐weighted images of the femoral condyles demonstrated focal areas of chondronecrosis, evidenced by pyknotic chondrocyte nuclei, loss of matrix staining, and altered MR image contrast. At increasing time points after surgery, progressive changes and eventual disappearance of abnormal cartilage canals were observed in areas of chondronecrosis by using QSM. Conclusion Abnormal cartilage canals were directly visualized in areas of surgically induced chondronecrosis. Quantitative susceptibility mapping enabled investigation of the vascular changes accompanying chondronecrosis in juvenile goats. Magn Reson Med 77:1276–1283, 2017. © 2016 International Society for Magnetic Resonance in Medicine" @default.
- W2307870967 created "2016-06-24" @default.
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- W2307870967 date "2016-03-28" @default.
- W2307870967 modified "2023-10-13" @default.
- W2307870967 title "Quantitative susceptibility mapping detects abnormalities in cartilage canals in a goat model of preclinical osteochondritis dissecans" @default.
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- W2307870967 doi "https://doi.org/10.1002/mrm.26214" @default.
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