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• W2307884312 startingPage "479" @default.
• W2307884312 abstract "Human African trypanosomiasis a fatal disease for which no vaccines exist and treatment regimens are difficult. Here, we evaluate a Trypanosoma brucei protein kinase, AEK1, as a potential drug target. Conditional knockouts confirmed AEK1 essentiality in bloodstream forms. For chemical validation, we overcame the lack of AEK1 inhibitors by creating parasites expressing a single, functional analog-sensitive AEK1 allele. Analog treatment of mice infected with this strain delayed parasitemia and death, with one-third of animals showing no parasitemia. These studies validate AEK1 as a drug target and highlight the need for further understanding of its function." @default.
• W2307884312 created "2016-06-24" @default.
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• W2307884312 date "2016-07-01" @default.
• W2307884312 modified "2023-10-15" @default.
• W2307884312 title "A novel protein kinase is essential in bloodstream Trypanosoma brucei" @default.
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• W2307884312 doi "https://doi.org/10.1016/j.ijpara.2016.03.001" @default.
• W2307884312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4925258" @default.
• W2307884312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27018127" @default.
• W2307884312 hasPublicationYear "2016" @default.
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