FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2307886479> ?p ?o ?g. }

• W2307886479 endingPage "150269" @default.
• W2307886479 startingPage "150269" @default.
• W2307886479 abstract "Streptococcus pneumoniaebacteria can be characterized into over 90 serotypes according to the composition of their polysaccharide capsules. Some serotypes are common in nasopharyngeal carriage whereas others are associated with invasive disease, but when carriage serotypes do invade disease is often particularly severe. It is unknown whether disease severity is due directly to the capsule type or to other virulence factors. Here, we used a clinical pneumococcal isolate and its capsule-switch mutants to determine the effect of capsule, in isolation from the genetic background, on severity of meningitis in an infant rat model. We found that possession of a capsule was essential for causing meningitis. Serotype 6B caused significantly more mortality than 7F and this correlated with increased capsule thickness in the cerebrospinal fluid (CSF), a stronger inflammatory cytokine response in the CSF and ultimately more cortical brain damage. We conclude that capsule type has a direct effect on meningitis severity. This is an important consideration in the current era of vaccination targeting a subset of capsule types that causes serotype replacement." @default.
• W2307886479 created "2016-06-24" @default.
• W2307886479 creator A5017956097 @default.
• W2307886479 creator A5022896497 @default.
• W2307886479 creator A5025369887 @default.
• W2307886479 creator A5025894006 @default.
• W2307886479 creator A5027771275 @default.
• W2307886479 date "2016-03-01" @default.
• W2307886479 modified "2023-10-12" @default.
• W2307886479 title "<i>Streptococcus pneumoniae</i>capsule determines disease severity in experimental pneumococcal meningitis" @default.
• W2307886479 cites W1663629741 @default.
• W2307886479 cites W1954112402 @default.
• W2307886479 cites W1967356976 @default.
• W2307886479 cites W1968363456 @default.
• W2307886479 cites W1976100756 @default.
• W2307886479 cites W1981040146 @default.
• W2307886479 cites W1985717406 @default.
• W2307886479 cites W1985881134 @default.
• W2307886479 cites W2001167483 @default.
• W2307886479 cites W2002020281 @default.
• W2307886479 cites W2011395715 @default.
• W2307886479 cites W2013572910 @default.
• W2307886479 cites W2023964275 @default.
• W2307886479 cites W2034043366 @default.
• W2307886479 cites W2040429518 @default.
• W2307886479 cites W2055290701 @default.
• W2307886479 cites W2087177871 @default.
• W2307886479 cites W2105008621 @default.
• W2307886479 cites W2109370421 @default.
• W2307886479 cites W2116979669 @default.
• W2307886479 cites W2121369371 @default.
• W2307886479 cites W2126767246 @default.
• W2307886479 cites W2142981860 @default.
• W2307886479 cites W2146413343 @default.
• W2307886479 cites W2153283925 @default.
• W2307886479 cites W2153842985 @default.
• W2307886479 cites W2154407429 @default.
• W2307886479 cites W2154820012 @default.
• W2307886479 cites W2161683931 @default.
• W2307886479 cites W2197518408 @default.
• W2307886479 cites W2200719717 @default.
• W2307886479 doi "https://doi.org/10.1098/rsob.150269" @default.
• W2307886479 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4821241" @default.
• W2307886479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27009189" @default.
• W2307886479 hasPublicationYear "2016" @default.
• W2307886479 type Work @default.
• W2307886479 sameAs 2307886479 @default.
• W2307886479 citedByCount "34" @default.
• W2307886479 countsByYear W23078864792016 @default.
• W2307886479 countsByYear W23078864792017 @default.
• W2307886479 countsByYear W23078864792018 @default.
• W2307886479 countsByYear W23078864792019 @default.
• W2307886479 countsByYear W23078864792020 @default.
• W2307886479 countsByYear W23078864792021 @default.
• W2307886479 countsByYear W23078864792022 @default.
• W2307886479 countsByYear W23078864792023 @default.
• W2307886479 crossrefType "journal-article" @default.
• W2307886479 hasAuthorship W2307886479A5017956097 @default.
• W2307886479 hasAuthorship W2307886479A5022896497 @default.
• W2307886479 hasAuthorship W2307886479A5025369887 @default.
• W2307886479 hasAuthorship W2307886479A5025894006 @default.
• W2307886479 hasAuthorship W2307886479A5027771275 @default.
• W2307886479 hasBestOaLocation W23078864791 @default.
• W2307886479 hasConcept C10389963 @default.
• W2307886479 hasConcept C104317684 @default.
• W2307886479 hasConcept C118552586 @default.
• W2307886479 hasConcept C142724271 @default.
• W2307886479 hasConcept C155292618 @default.
• W2307886479 hasConcept C159047783 @default.
• W2307886479 hasConcept C169760540 @default.
• W2307886479 hasConcept C203014093 @default.
• W2307886479 hasConcept C22070199 @default.
• W2307886479 hasConcept C2776152631 @default.
• W2307886479 hasConcept C2778778583 @default.
• W2307886479 hasConcept C2779134260 @default.
• W2307886479 hasConcept C2779651940 @default.
• W2307886479 hasConcept C2781026528 @default.
• W2307886479 hasConcept C2781253189 @default.
• W2307886479 hasConcept C32762888 @default.
• W2307886479 hasConcept C501593827 @default.
• W2307886479 hasConcept C55493867 @default.
• W2307886479 hasConcept C59822182 @default.
• W2307886479 hasConcept C60987743 @default.
• W2307886479 hasConcept C71924100 @default.
• W2307886479 hasConcept C86803240 @default.
• W2307886479 hasConcept C89423630 @default.
• W2307886479 hasConceptScore W2307886479C10389963 @default.
• W2307886479 hasConceptScore W2307886479C104317684 @default.
• W2307886479 hasConceptScore W2307886479C118552586 @default.
• W2307886479 hasConceptScore W2307886479C142724271 @default.
• W2307886479 hasConceptScore W2307886479C155292618 @default.
• W2307886479 hasConceptScore W2307886479C159047783 @default.
• W2307886479 hasConceptScore W2307886479C169760540 @default.
• W2307886479 hasConceptScore W2307886479C203014093 @default.
• W2307886479 hasConceptScore W2307886479C22070199 @default.
• W2307886479 hasConceptScore W2307886479C2776152631 @default.
• W2307886479 hasConceptScore W2307886479C2778778583 @default.
• W2307886479 hasConceptScore W2307886479C2779134260 @default.

• next