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• W2307954707 abstract "Compared to conventional deep brain stimulation (DBS) for patients with Parkinson's Disease (PD), the newer approach of adaptive DBS (aDBS), regulating stimulation on the basis of the patient's clinical state, promises to achieve better clinical outcomes, avoid adverse-effects and save time for tuning parameters. A remaining challenge before aDBS comes into practical use is to prove its feasibility and its effectiveness in larger groups of patients and in more ecological conditions. We developed an external portable aDBS system prototype designed for clinical testing in freely-moving PD patients with externalized DBS electrodes. From a single-channel bipolar artifact-free recording, it analyses local field potentials (LFPs), during ongoing DBS for tuning stimulation parameters, independent from the specific feedback algorithm implemented. We validated the aDBS system in vitro, by testing both its sensing and closed-loop stimulation capabilities, and then tested it in vivo, focusing on the sensing capabilities. By applying the aDBS system prototype in a patient with PD, we provided evidence that it can track levodopa and DBS-induced LFP spectral power changes among different patient's clinical states. Our system, intended for testing LFP-based feedback strategies for aDBS, should help understanding how and whether aDBS therapy works in PD and indicating future technical and clinical advances." @default.
• W2307954707 created "2016-06-24" @default.
• W2307954707 creator A5015579475 @default.
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• W2307954707 date "2016-05-01" @default.
• W2307954707 modified "2023-10-07" @default.
• W2307954707 title "An external portable device for adaptive deep brain stimulation (aDBS) clinical research in advanced Parkinson's Disease" @default.
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• W2307954707 doi "https://doi.org/10.1016/j.medengphy.2016.02.007" @default.
• W2307954707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27029510" @default.
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