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- W2308043819 endingPage "1241" @default.
- W2308043819 startingPage "1234" @default.
- W2308043819 abstract "Abstract Thrombocytopenia is defined as a status in which platelet numbers are reduced. Imbalance between the homeostatic regulation of platelet generation and destruction is 1 potential cause of thrombocytopenia. In adults, platelet generation is a 2-stage process entailing the differentiation of hematopoietic stem cells into mature megakaryocytes (MKs; known as megakaryopoiesis) and release of platelets from MKs (known as thrombopoiesis or platelet biogenesis). Until recently, information about the genetic defects responsible for congenital thrombocytopenia was only available for a few forms of the disease. However, investigations over the past 15 years have identified mutations in genes encoding >20 different proteins that are responsible for these disorders, which has advanced our understanding of megakaryopoiesis and thrombopoiesis. The underlying pathogenic mechanisms can be categorized as (1) defects in MK lineage commitment and differentiation, (2) defects in MK maturation, and (3) defect in platelet release. Using these developmental stage categories, we here update recently described mechanisms underlying megakaryopoiesis and thrombopoiesis and discuss the association between platelet generation systems and thrombocytopenia." @default.
- W2308043819 created "2016-06-24" @default.
- W2308043819 creator A5026458340 @default.
- W2308043819 creator A5030750112 @default.
- W2308043819 date "2016-03-10" @default.
- W2308043819 modified "2023-09-30" @default.
- W2308043819 title "Linkage between the mechanisms of thrombocytopenia and thrombopoiesis" @default.
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