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- W2308144791 endingPage "327" @default.
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- W2308144791 abstract "There are currently no clinically available inhibitors of metallo-β-lactamases (MBLs). These enzymes confer resistance to bacteria against a broad range of commonly used β-lactam antibiotics, and are produced by an increasing number of bacterial pathogens. In this study, several thiol derivatives of l-amino acids were designed and synthesized, and their inhibitory effects against the metallo-β-lactamase IMP-1 (subclass B1) were investigated. The most potent compound, derived from l-tyrosine, exhibited competitive inhibition, with a Ki of 86 nM. The ability of this compound to render MBL-expressing bacteria susceptible to imipenem was examined. Reductions in MIC values up to 5.2—fold were observed." @default.
- W2308144791 created "2016-06-24" @default.
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- W2308144791 date "2016-05-01" @default.
- W2308144791 modified "2023-10-08" @default.
- W2308144791 title "Design, synthesis, and in vitro and biological evaluation of potent amino acid-derived thiol inhibitors of the metallo-β-lactamase IMP-1" @default.
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- W2308144791 doi "https://doi.org/10.1016/j.ejmech.2016.03.017" @default.
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