Matches in SemOpenAlex for { <https://semopenalex.org/work/W2308179925> ?p ?o ?g. }
- W2308179925 endingPage "690" @default.
- W2308179925 startingPage "678" @default.
- W2308179925 abstract "Recently, we have reported that N-adamantyl-4-methylthiazol-2-amine (KHG26693) successfully reduced the production of oxidative stress in streptozotocin-induced diabetic rats and lipopolysaccharide-induced BV-2 microglial cells by increasing their antioxidant capacity. However, antioxidative effects of KHG26693 against Aβ (Aβ)-induced oxidative stress have not yet been reported. In the present study, we further investigated the antioxidative function of KHG26693 in Aβ-mediated primary cultured cortical neurons. We showed here that KHG26693 attenuated Aβ-induced cytotoxicity, increase of Bax/Bcl-2 ratio, elevation of caspase-3 expression, and impairment of mitochondrial membrane potential in cultured primary cortical neurons. KHG26693 also decreases the Aβ-mediated formation of malondialdehyde, reactive oxygen species, and NO production by decreasing nitric oxide synthase (iNOS) and NADPH oxidase level. Moreover, KHG26693 suppress the Aβ-induced oxidative stress through a possible mechanism involving attenuation of GSH and antioxidant enzyme activities such as glutathione reductase and glutathione peroxidase (GPx). Finally, pretreatment of cortical neurons with KHG26693 significantly reduced the Aβ-induced protein oxidation and nitration. To our knowledge, this is the first report, showing that KHG26693 significantly attenuates Aβ-induced oxidative stress in primary cortical neurons, and may prove attractive strategies to reduce Aβ-induced neural cell death." @default.
- W2308179925 created "2016-06-24" @default.
- W2308179925 creator A5021338398 @default.
- W2308179925 creator A5043659616 @default.
- W2308179925 creator A5049884810 @default.
- W2308179925 creator A5069021637 @default.
- W2308179925 creator A5078229156 @default.
- W2308179925 creator A5088571367 @default.
- W2308179925 date "2016-04-25" @default.
- W2308179925 modified "2023-10-16" @default.
- W2308179925 title "<i>N</i>-Adamantyl-4-methylthiazol-2-amine suppresses amyloid β-induced neuronal oxidative damage in cortical neurons" @default.
- W2308179925 cites W1495997476 @default.
- W2308179925 cites W1513568277 @default.
- W2308179925 cites W1542215809 @default.
- W2308179925 cites W1557493371 @default.
- W2308179925 cites W1570513132 @default.
- W2308179925 cites W1662308449 @default.
- W2308179925 cites W1755191730 @default.
- W2308179925 cites W183120241 @default.
- W2308179925 cites W1835478781 @default.
- W2308179925 cites W1977323286 @default.
- W2308179925 cites W1980204153 @default.
- W2308179925 cites W1981377196 @default.
- W2308179925 cites W1990497150 @default.
- W2308179925 cites W1990553465 @default.
- W2308179925 cites W1992772000 @default.
- W2308179925 cites W1993681053 @default.
- W2308179925 cites W1996562399 @default.
- W2308179925 cites W1998849703 @default.
- W2308179925 cites W1999896880 @default.
- W2308179925 cites W2001614782 @default.
- W2308179925 cites W2010484888 @default.
- W2308179925 cites W2015197787 @default.
- W2308179925 cites W2017115444 @default.
- W2308179925 cites W2022396367 @default.
- W2308179925 cites W2034621801 @default.
- W2308179925 cites W2035248740 @default.
- W2308179925 cites W2035612133 @default.
- W2308179925 cites W2036391216 @default.
- W2308179925 cites W2041515345 @default.
- W2308179925 cites W2041767244 @default.
- W2308179925 cites W2044395254 @default.
- W2308179925 cites W2052089807 @default.
- W2308179925 cites W2053749461 @default.
- W2308179925 cites W2054580670 @default.
- W2308179925 cites W2054874422 @default.
- W2308179925 cites W2055600273 @default.
- W2308179925 cites W2055672277 @default.
- W2308179925 cites W2058472591 @default.
- W2308179925 cites W2058638060 @default.
- W2308179925 cites W2065828987 @default.
- W2308179925 cites W2068318042 @default.
- W2308179925 cites W2070105814 @default.
- W2308179925 cites W2075209098 @default.
- W2308179925 cites W2081711461 @default.
- W2308179925 cites W2083968759 @default.
- W2308179925 cites W2085278496 @default.
- W2308179925 cites W2086377942 @default.
- W2308179925 cites W2087303538 @default.
- W2308179925 cites W2088881207 @default.
- W2308179925 cites W2091711919 @default.
- W2308179925 cites W2104194752 @default.
- W2308179925 cites W2105704879 @default.
- W2308179925 cites W2106406927 @default.
- W2308179925 cites W2107120526 @default.
- W2308179925 cites W2124634545 @default.
- W2308179925 cites W2129224791 @default.
- W2308179925 cites W2135888844 @default.
- W2308179925 cites W2137580576 @default.
- W2308179925 cites W2138006799 @default.
- W2308179925 cites W2144535585 @default.
- W2308179925 cites W2146342401 @default.
- W2308179925 cites W2150074066 @default.
- W2308179925 cites W2158708637 @default.
- W2308179925 cites W2163290644 @default.
- W2308179925 cites W2170644926 @default.
- W2308179925 cites W2183291427 @default.
- W2308179925 cites W2184190506 @default.
- W2308179925 cites W2250660834 @default.
- W2308179925 cites W4293247451 @default.
- W2308179925 cites W75763855 @default.
- W2308179925 doi "https://doi.org/10.3109/10715762.2016.1167277" @default.
- W2308179925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27002191" @default.
- W2308179925 hasPublicationYear "2016" @default.
- W2308179925 type Work @default.
- W2308179925 sameAs 2308179925 @default.
- W2308179925 citedByCount "21" @default.
- W2308179925 countsByYear W23081799252016 @default.
- W2308179925 countsByYear W23081799252017 @default.
- W2308179925 countsByYear W23081799252018 @default.
- W2308179925 countsByYear W23081799252019 @default.
- W2308179925 countsByYear W23081799252020 @default.
- W2308179925 countsByYear W23081799252021 @default.
- W2308179925 countsByYear W23081799252022 @default.
- W2308179925 countsByYear W23081799252023 @default.
- W2308179925 crossrefType "journal-article" @default.
- W2308179925 hasAuthorship W2308179925A5021338398 @default.
- W2308179925 hasAuthorship W2308179925A5043659616 @default.