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- W2308196586 abstract "Investigations into a previously unexplained condition of leg swelling in feedlot cattle have demonstrated a relationship with low vitamin E levels and have revealed one of the predisposing causes of death from heat stress. This study began when a summer-associated condition of swelling of the hind legs was reported in feedlot cattle (>2 months on feed) in NSW and Queensland. The condition occurred during prolonged hot weather; improvement occurred after the onset of cooler weather. It was fast observed as lameness, fluid swelling of the hock joint, progressing to generalised swelling down to the hoofs and sometimes up to the groin. The skin directly above the hoof and around the pastern was reddened, swollen and tight. Microscopic examination of the lower leg revealed marked changes in small blood vessels with a resultant outpouring of fluid into surrounding tissues. The changes were similar to those described in other animal species, in particular pigs and poultry, with antioxidant deficiency. Antioxidants, especially vitamin E, stabilise membranes protecting them from free radical attack. Endothelial cells of blood vessels can be a target for fi=ee radicals with resultant vessel damage, fragility and leakage. As a consequence, antioxidant levels in feed, serum and tissue, as well as other possible contributing factors, were studied. Feedlot cattle with leg swelling or death from heat stress consistently had nil or low vitamin E supplementation and low serum/tissue levels. Secondary dietary factors which may have exacerbated the condition were high levels of fat (tallow or whole cotton seed), rancidity, high levels of carbohydrate and lactic acidosis, fungal contamination, nitrites, ionophors and an imbalance of omega 3 and omega 6 fatty acids. From our studies, feedlot cattle have very low levels of linolenic acid (an omega 3 fatty acid) compared with grazing animals (up to 100 fold difference). One of the roles of vitamin E is to control the formation of prostaglandins, although omega 3 fatty acids are significantly more effective in this role by effectively decreasing the capacity for the synthesis of leukotrienes and prostaglandins, compounds which can increase vascular permeability." @default.
- W2308196586 created "2016-06-24" @default.
- W2308196586 creator A5085002894 @default.
- W2308196586 date "1997-01-01" @default.
- W2308196586 modified "2023-09-27" @default.
- W2308196586 title "Vascular damage and heat stress related to low antioxidant levels in feedlot cattle rations." @default.
- W2308196586 hasPublicationYear "1997" @default.
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