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• W2308222267 endingPage "360" @default.
• W2308222267 startingPage "353" @default.
• W2308222267 abstract "Exposure to alcohol alters many physiological processes, including endocrine status. The present study examined whether prolonged alcohol (A) exposure could modulate selected stereological and hormonal aspects of pituitary somatotrophs (growth hormone-GH cells) and corticotrophs (adrenocorticotropic hormone-ACTH cells) in adult rats. Changes in pituitary gland volume; the volume density, total number and volume of GH and ACTH cells following alcohol exposure were evaluated using a stereological system (newCAST), while peripheral GH and ACTH levels were determined biochemically. Our results demonstrated the reduction (p < 0.05) of the volume density (37%) and volume of GH cells (29%) in the group A. Also, there was a tendency for the total number of GH cells to be smaller in the group A. Serum GH level was significantly decreased (p < 0.05; 70%) in the group A when compared to control values. Moreover, prolonged alcohol exposure induced declines (p < 0.05) in volume density (24%) and volume of ACTH cells (29%). The total number of ACTH cells and ACTH level were higher (p < 0.05; 42%) in the group A than in control rats. Collectively, these results indicate that prolonged alcohol exposure leads not only to changes in GH and ACTH hormone levels, but also to alterations of the morphological aspects of GH and ACTH cells within the pituitary." @default.
• W2308222267 created "2016-06-24" @default.
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• W2308222267 date "2016-05-01" @default.
• W2308222267 modified "2023-09-27" @default.
• W2308222267 title "Effects of prolonged alcohol exposure on somatotrophs and corticotrophs in adult rats: Stereological and hormonal study" @default.
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• W2308222267 doi "https://doi.org/10.1016/j.acthis.2016.03.005" @default.
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• W2308222267 hasPublicationYear "2016" @default.
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