FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2308242715> ?p ?o ?g. }

• W2308242715 endingPage "56" @default.
• W2308242715 startingPage "1349" @default.
• W2308242715 abstract "Effects of the trans-isomer of 2-en-valproate (trans-2-en-NaVP; E-delta2-en-valproate or 2-en-valproate), an unsaturated metabolite of valproic acid (VPA), on intracellularly recorded sodium-dependent action potentials of cultured mouse spinal cord and cortical neurons were compared with those of the anticonvulsant sodium valproate (NaVP). The maximal rate of rise of action potentials triggered by trains of 1-msec or 400-msec pulses declined progressively until failure to fire in both cell types during exposure to trans-2-en-NaVP or NaVP was observed. The limitation of firing by both drugs was concentration, voltage, rate and time dependent. The IC50 of trans-2-en-NaVP was 1.2 x 10(-3) at < or =1 hr and 4.8 x 10(-5) M at 24 to 48 hr. Trans-2-en-NaVP did not limit sustained repetitive firing in all cortical neurons. This may reflect slower rates of firing during 400-msec depolarizations in neurons of this type. In paired-pulse experiments, the absolute refractory period was 7 msec in control solution and 15 msec (P < .01 vs. control; n = 9) in solution containing 6 x 10(-4) M trans-2-en-NaVP. Firing was limited in all spinal cord neurons after exposure to 0.5 mM NaVP for 24 to 48 hr; 80% were limited by 1 mM NaVP at < or =1 hr. Coincubation of the spinal cord neurons with trans-2-en-NaVP and NaVP for 24 hr showed no hyperadditive effect of these two drugs in vitro. Limitation of sustained repetitive firing was reversed by hyperpolarization in the continuing presence of either drug and incubation in drug-free medium. Limitation of sodium-dependent action potential firing rates could contribute, at least in part, to the anticonvulsant effect of trans-2-en-NaVP." @default.
• W2308242715 created "2016-06-24" @default.
• W2308242715 creator A5010235451 @default.
• W2308242715 creator A5037157268 @default.
• W2308242715 creator A5073513408 @default.
• W2308242715 date "1997-03-01" @default.
• W2308242715 modified "2023-09-23" @default.
• W2308242715 title "Trans-2-en-valproic acid limits action potential firing frequency in mouse central neurons in cell culture." @default.
• W2308242715 cites W1762877386 @default.
• W2308242715 cites W1879798186 @default.
• W2308242715 cites W1932082741 @default.
• W2308242715 cites W1935237016 @default.
• W2308242715 cites W1939812731 @default.
• W2308242715 cites W1981126050 @default.
• W2308242715 cites W1982249577 @default.
• W2308242715 cites W1993618451 @default.
• W2308242715 cites W1994862483 @default.
• W2308242715 cites W1998926766 @default.
• W2308242715 cites W2000952157 @default.
• W2308242715 cites W2018671604 @default.
• W2308242715 cites W2022585347 @default.
• W2308242715 cites W2023518878 @default.
• W2308242715 cites W2030852821 @default.
• W2308242715 cites W2031062317 @default.
• W2308242715 cites W2036162690 @default.
• W2308242715 cites W2053685640 @default.
• W2308242715 cites W2067276282 @default.
• W2308242715 cites W2071708159 @default.
• W2308242715 cites W2074144357 @default.
• W2308242715 cites W2075301750 @default.
• W2308242715 cites W2075377255 @default.
• W2308242715 cites W2091064465 @default.
• W2308242715 cites W2095088563 @default.
• W2308242715 cites W2097145992 @default.
• W2308242715 cites W2158386281 @default.
• W2308242715 cites W2171792670 @default.
• W2308242715 cites W2320058521 @default.
• W2308242715 cites W2322086287 @default.
• W2308242715 cites W2341791471 @default.
• W2308242715 cites W2365924967 @default.
• W2308242715 cites W2407306484 @default.
• W2308242715 cites W2430472395 @default.
• W2308242715 cites W34455977 @default.
• W2308242715 cites W2154277990 @default.
• W2308242715 cites W2414138044 @default.
• W2308242715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9067323" @default.
• W2308242715 hasPublicationYear "1997" @default.
• W2308242715 type Work @default.
• W2308242715 sameAs 2308242715 @default.
• W2308242715 citedByCount "4" @default.
• W2308242715 crossrefType "journal-article" @default.
• W2308242715 hasAuthorship W2308242715A5010235451 @default.
• W2308242715 hasAuthorship W2308242715A5037157268 @default.
• W2308242715 hasAuthorship W2308242715A5073513408 @default.
• W2308242715 hasConcept C126322002 @default.
• W2308242715 hasConcept C134018914 @default.
• W2308242715 hasConcept C169760540 @default.
• W2308242715 hasConcept C17077164 @default.
• W2308242715 hasConcept C178790620 @default.
• W2308242715 hasConcept C185263204 @default.
• W2308242715 hasConcept C185592680 @default.
• W2308242715 hasConcept C2775858608 @default.
• W2308242715 hasConcept C2777172819 @default.
• W2308242715 hasConcept C2777477808 @default.
• W2308242715 hasConcept C2778186239 @default.
• W2308242715 hasConcept C2780775167 @default.
• W2308242715 hasConcept C537181965 @default.
• W2308242715 hasConcept C55493867 @default.
• W2308242715 hasConcept C70616116 @default.
• W2308242715 hasConcept C71924100 @default.
• W2308242715 hasConcept C86803240 @default.
• W2308242715 hasConcept C98274493 @default.
• W2308242715 hasConceptScore W2308242715C126322002 @default.
• W2308242715 hasConceptScore W2308242715C134018914 @default.
• W2308242715 hasConceptScore W2308242715C169760540 @default.
• W2308242715 hasConceptScore W2308242715C17077164 @default.
• W2308242715 hasConceptScore W2308242715C178790620 @default.
• W2308242715 hasConceptScore W2308242715C185263204 @default.
• W2308242715 hasConceptScore W2308242715C185592680 @default.
• W2308242715 hasConceptScore W2308242715C2775858608 @default.
• W2308242715 hasConceptScore W2308242715C2777172819 @default.
• W2308242715 hasConceptScore W2308242715C2777477808 @default.
• W2308242715 hasConceptScore W2308242715C2778186239 @default.
• W2308242715 hasConceptScore W2308242715C2780775167 @default.
• W2308242715 hasConceptScore W2308242715C537181965 @default.
• W2308242715 hasConceptScore W2308242715C55493867 @default.
• W2308242715 hasConceptScore W2308242715C70616116 @default.
• W2308242715 hasConceptScore W2308242715C71924100 @default.
• W2308242715 hasConceptScore W2308242715C86803240 @default.
• W2308242715 hasConceptScore W2308242715C98274493 @default.
• W2308242715 hasIssue "3" @default.
• W2308242715 hasLocation W23082427151 @default.
• W2308242715 hasOpenAccess W2308242715 @default.
• W2308242715 hasPrimaryLocation W23082427151 @default.
• W2308242715 hasRelatedWork W2016777209 @default.
• W2308242715 hasRelatedWork W2018759446 @default.
• W2308242715 hasRelatedWork W2027216937 @default.
• W2308242715 hasRelatedWork W2043655363 @default.

• next