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- W2308306656 endingPage "20" @default.
- W2308306656 startingPage "4808" @default.
- W2308306656 abstract "Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of senile dementia all over the world. Still no existing drugs can effectively reverse the cognitive impairment. However, Sigma-1 (σ-1) receptors have been long implicated in multiple neurological and psychiatric conditions over these years. In this review, we discuss the current understanding of σ-1 receptor functions. Through regulation of lipid rafts, secretases, kinases, neuroceptors and ion channels, σ-1 receptors can influence cellular signal transduction, TCA cycle, oxidative stress, neuron plasticity and neurotransmitter release etc. Based on this, we suggest the key cellular mechanisms linking σ-1 receptor to Alzheimer's disease. Besides, we detail the evidences showing that σ-1 receptors agonists, being the promising compounds for treatment of cognitive dysfunction, exhibit robust neuroprotection and anti-amnesia effect against Aβ neurotoxicity in the progress of Alzheimer's disease. The evidence comes from animal models, preclinical studies in humans and full clinical trials. In addition, the questions to be solved regarding this receptor are also presented. When concerned with NMDAR, σ-1 receptor activation may result in two totally different influences on AD. Utilization of σ-1 agents early in AD remains an overlooked therapeutic opportunity. This article may pave the way for further studies about sigma-1 receptor on Alzheimer's disease." @default.
- W2308306656 created "2016-06-24" @default.
- W2308306656 creator A5011788511 @default.
- W2308306656 creator A5025891691 @default.
- W2308306656 creator A5029718321 @default.
- W2308306656 creator A5069216833 @default.
- W2308306656 date "2015-01-01" @default.
- W2308306656 modified "2023-10-14" @default.
- W2308306656 title "Roles of sigma-1 receptors in Alzheimer's disease." @default.
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