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- W2308354727 abstract "See related articles, p 39, p 45, and p 50 tions aimed at preventing and treating RDS, namely antenatal corticosteroids (ACS) and surfactant treatment. There are nowmultiple interventions to assist the premature infant during this transition including ACS, surfactant, monitored administration of supplemental oxygen, and sophisticated mechanical ventilators. With these advances, neonatology has witnessed an improvement in survival of the smallest, most premature neonates and pushed the threshold of viability to 22weeks’ gestational age (GA). With improved survival of these infants, clinicians are now asking “Canwe improve seriousmorbidities such as bronchopulmonary dysplasia (BPD)?” Infants diagnosed with BPD are at higher risk of poor pulmonary and neurodevelopmental outcomes. Recent randomized controlled trials (RCTs) consistently demonstrate that early, routine use of nasal continuous positive airway pressure (CPAP) can decrease BPD. However, the treatment effect is small, which may be related to the high rate of CPAP failure resulting in a need for mechanical ventilation. Nonetheless, reducing CPAP failure might enhance efficacy of CPAP therapy to prevent BPD. Here, we review the evidence that supports routine use of CPAP to prevent neonatal lung injury. We discuss criteria to define CPAP failure, and review both proven and emerging therapies to optimize successful implementation of CPAP." @default.
- W2308354727 created "2016-06-24" @default.
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- W2308354727 date "2016-06-01" @default.
- W2308354727 modified "2023-09-27" @default.
- W2308354727 title "Continuous Positive Airway Pressure to Prevent Neonatal Lung Injury: How Did We Get Here, and How Do We Improve?" @default.
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- W2308354727 doi "https://doi.org/10.1016/j.jpeds.2016.02.059" @default.
- W2308354727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27025910" @default.
- W2308354727 hasPublicationYear "2016" @default.
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