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• W2308356239 abstract "Summary T‐cell immunoglobulin and mucin ( TIM ) family molecules are cell membrane proteins, preferentially expressed on various immune cells and implicated in recognition and clearance of apoptotic cells. Little is known of their function outside human and mouse, and nothing outside mammals. We identified only two TIM genes ( ch TIM ) in the chicken genome, putative orthologues of mammalian TIM 1 and TIM 4 , and cloned the respective cDNA s. Like mammalian TIM 1 , ch TIM 1 expression was restricted to lymphoid tissues and immune cells. The gene ch TIM 4 encodes at least five splice variants with distinct expression profiles that also varied between strains of chicken. Expression of ch TIM 4 was detected in myeloid antigen‐presenting cells, and in γδ T cells, whereas mammalian TIM 4 is not expressed in T cells. Like the mammalian proteins, ch TIM 1 and ch TIM 4 fusion proteins bind to phosphatidylserine, and are thereby implicated in recognition of apoptotic cells. The ch TIM 4–immunoglobulin fusion protein also had co‐stimulatory activity on chicken T cells, suggesting a function in antigen presentation." @default.
• W2308356239 created "2016-06-24" @default.
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• W2308356239 date "2016-06-20" @default.
• W2308356239 modified "2023-10-03" @default.
• W2308356239 title "Functional annotation of the T-cell immunoglobulin mucin family in birds" @default.
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• W2308356239 doi "https://doi.org/10.1111/imm.12607" @default.
• W2308356239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4913284" @default.
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• W2308356239 hasPublicationYear "2016" @default.
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