FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2308373504> ?p ?o ?g. }

• W2308373504 endingPage "3082" @default.
• W2308373504 startingPage "3074" @default.
• W2308373504 abstract "Thrombopoietin (TPO) is implicated as a primary regulator of megakaryopoiesis and thrombopoiesis. However, the biologic effects of TPO on human acute myeloblastic leukemia (AML) cells are largely unknown. To determine if recombinant human (rh) TPO has proliferation-supporting and differentiation-inducing activities in AML cells, 15 cases of AML cells that were exclusively composed of undifferentiated leukemia cells and showed growth response to rhTPO in a short-term culture (72 hours) were subjected to long-term suspension culture with or without rhTPO. Of 15 cases, rhTPO supported proliferation of AML cells for 2 to 4 weeks in 4 cases whose French-American-British subtypes were M0, M2, M4, and M7, respectively. In addition to the proliferation-supporting activity, rhTPO was found to induce AML cells to progress to some degree of megakaryocytic differentiation at both morphologic and surface-phenotypic level in 2 AML cases with M0 and M7 subtypes. The treatment of AML cells with rhTPO resulted in rapid tyrosine phosphorylation of the TPO-receptor, c-mpl, and STAT3 in all of cases tested. By contrast, the expression of erythroid/megakaryocyte-specific transcription factors (GATA-1, GATA-2, and NF-E2) was markedly induced or enhanced in only 2 AML cases that showed megakaryocytic differentiation in response to rhTPO. These results suggested that, at least in a fraction of AML cases, TPO could not only support the proliferation of AML cells irrespective of AML subtypes, but could also induce megakaryocytic differentiation, possibly through activation of GATA-1, GATA-2, and NF-E2." @default.
• W2308373504 created "2016-06-24" @default.
• W2308373504 creator A5019303848 @default.
• W2308373504 creator A5021701878 @default.
• W2308373504 creator A5030091429 @default.
• W2308373504 creator A5040177352 @default.
• W2308373504 creator A5042578319 @default.
• W2308373504 creator A5045269393 @default.
• W2308373504 creator A5045468227 @default.
• W2308373504 creator A5046715170 @default.
• W2308373504 creator A5055453369 @default.
• W2308373504 creator A5080908654 @default.
• W2308373504 creator A5086129270 @default.
• W2308373504 date "1996-10-15" @default.
• W2308373504 modified "2023-10-03" @default.
• W2308373504 title "The biologic properties of recombinant human thrombopoietin in the proliferation and megakaryocytic differentiation of acute myeloblastic leukemia cells" @default.
• W2308373504 cites W124601896 @default.
• W2308373504 cites W125588914 @default.
• W2308373504 cites W143865877 @default.
• W2308373504 cites W1526058544 @default.
• W2308373504 cites W1538909114 @default.
• W2308373504 cites W1562376535 @default.
• W2308373504 cites W1563224204 @default.
• W2308373504 cites W1625545766 @default.
• W2308373504 cites W1865033903 @default.
• W2308373504 cites W189385581 @default.
• W2308373504 cites W1965375035 @default.
• W2308373504 cites W197013897 @default.
• W2308373504 cites W1970189927 @default.
• W2308373504 cites W1971045715 @default.
• W2308373504 cites W1971987125 @default.
• W2308373504 cites W1983612778 @default.
• W2308373504 cites W1987686674 @default.
• W2308373504 cites W199379996 @default.
• W2308373504 cites W1995780901 @default.
• W2308373504 cites W1996093792 @default.
• W2308373504 cites W1997632886 @default.
• W2308373504 cites W2001643449 @default.
• W2308373504 cites W200722710 @default.
• W2308373504 cites W2011722739 @default.
• W2308373504 cites W2022261377 @default.
• W2308373504 cites W2038818733 @default.
• W2308373504 cites W2053487253 @default.
• W2308373504 cites W2055568103 @default.
• W2308373504 cites W2056128616 @default.
• W2308373504 cites W2065810182 @default.
• W2308373504 cites W2067190714 @default.
• W2308373504 cites W2081185151 @default.
• W2308373504 cites W2081923886 @default.
• W2308373504 cites W2093758335 @default.
• W2308373504 cites W2114918609 @default.
• W2308373504 cites W2133151289 @default.
• W2308373504 cites W2143531841 @default.
• W2308373504 cites W2147213204 @default.
• W2308373504 cites W2257147464 @default.
• W2308373504 cites W2272268908 @default.
• W2308373504 cites W2279158789 @default.
• W2308373504 cites W2394641347 @default.
• W2308373504 cites W2407201344 @default.
• W2308373504 cites W2411246781 @default.
• W2308373504 cites W2412348981 @default.
• W2308373504 cites W2413648258 @default.
• W2308373504 cites W2415780251 @default.
• W2308373504 cites W2463098068 @default.
• W2308373504 cites W2472459397 @default.
• W2308373504 cites W69990049 @default.
• W2308373504 cites W90048484 @default.
• W2308373504 cites W1910650786 @default.
• W2308373504 doi "https://doi.org/10.1182/blood.v88.8.3074.bloodjournal8883074" @default.
• W2308373504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8874206" @default.
• W2308373504 hasPublicationYear "1996" @default.
• W2308373504 type Work @default.
• W2308373504 sameAs 2308373504 @default.
• W2308373504 citedByCount "34" @default.
• W2308373504 countsByYear W23083735042015 @default.
• W2308373504 crossrefType "journal-article" @default.
• W2308373504 hasAuthorship W2308373504A5019303848 @default.
• W2308373504 hasAuthorship W2308373504A5021701878 @default.
• W2308373504 hasAuthorship W2308373504A5030091429 @default.
• W2308373504 hasAuthorship W2308373504A5040177352 @default.
• W2308373504 hasAuthorship W2308373504A5042578319 @default.
• W2308373504 hasAuthorship W2308373504A5045269393 @default.
• W2308373504 hasAuthorship W2308373504A5045468227 @default.
• W2308373504 hasAuthorship W2308373504A5046715170 @default.
• W2308373504 hasAuthorship W2308373504A5055453369 @default.
• W2308373504 hasAuthorship W2308373504A5080908654 @default.
• W2308373504 hasAuthorship W2308373504A5086129270 @default.
• W2308373504 hasBestOaLocation W23083735041 @default.
• W2308373504 hasConcept C104317684 @default.
• W2308373504 hasConcept C109159458 @default.
• W2308373504 hasConcept C148738053 @default.
• W2308373504 hasConcept C203014093 @default.
• W2308373504 hasConcept C2776601000 @default.
• W2308373504 hasConcept C2776958478 @default.
• W2308373504 hasConcept C2777553839 @default.
• W2308373504 hasConcept C2777863708 @default.
• W2308373504 hasConcept C2777918643 @default.
• W2308373504 hasConcept C2778461978 @default.

• next