Matches in SemOpenAlex for { <https://semopenalex.org/work/W2308382434> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2308382434 endingPage "238" @default.
- W2308382434 startingPage "232" @default.
- W2308382434 abstract "Purpose To evaluate the level of transforming growth factor-β2 (TGF-β2) in the aqueous humor of highly myopic cataract patients and its correlation with capsule contraction syndrome. Setting Eye and ENT Hospital of Fudan University, Shanghai, China. Design Prospective comparative case series. Methods The highly myopic cataract patients were divided into the following 2 groups according to the Lens Opacity Classification System III: nuclear color (NC) 2 to 3 and NC 5 to 6. Aqueous humor TGF-β2 concentrations were assayed in the highly myopic cataract and age-related cataract groups. The TGF-β2, TGF-βRII (the type II receptor for TGF-β2), and α-smooth muscle actin (α-SMA) expressions in lens epithelial cells (LECs) were detected by real-time polymerase chain reaction and immunofluorescent staining. Results The study comprised 40 highly myopic cataract patients (40 eyes) and 20 patients (20 eyes) with age-related cataract as the control group. Compared with the control group, the highly myopic cataract group had significantly higher TGF-β2 concentration in the aqueous humor and increased TGF-βRII expression in LECs, especially in NC 5 to 6 cases. Expression of α-SMA was barely detectable in both groups. Conclusion In highly myopic cataract patients, especially those with dark nuclei, elevated aqueous humor TGF-β2 levels and the upregulated TGF-βRII expression in LECs might contribute to the pathogenesis of capsule contraction syndrome through transdifferentiation of LECs into myofibroblasts. Financial Disclosure None of the authors has a financial or proprietary interest in any material or method mentioned." @default.
- W2308382434 created "2016-06-24" @default.
- W2308382434 creator A5008413606 @default.
- W2308382434 creator A5030152455 @default.
- W2308382434 creator A5031973253 @default.
- W2308382434 creator A5041307931 @default.
- W2308382434 creator A5084225297 @default.
- W2308382434 date "2016-02-01" @default.
- W2308382434 modified "2023-10-18" @default.
- W2308382434 title "Elevated TGF-β2 level in aqueous humor of cataract patients with high myopia: Potential risk factor for capsule contraction syndrome" @default.
- W2308382434 cites W1977965683 @default.
- W2308382434 cites W1983759652 @default.
- W2308382434 cites W1984337600 @default.
- W2308382434 cites W1991523453 @default.
- W2308382434 cites W2010726122 @default.
- W2308382434 cites W2011445196 @default.
- W2308382434 cites W2014900240 @default.
- W2308382434 cites W2095138314 @default.
- W2308382434 cites W2114619129 @default.
- W2308382434 cites W2161286541 @default.
- W2308382434 cites W2170786019 @default.
- W2308382434 cites W2441458973 @default.
- W2308382434 doi "https://doi.org/10.1016/j.jcrs.2015.09.027" @default.
- W2308382434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27026447" @default.
- W2308382434 hasPublicationYear "2016" @default.
- W2308382434 type Work @default.
- W2308382434 sameAs 2308382434 @default.
- W2308382434 citedByCount "21" @default.
- W2308382434 countsByYear W23083824342017 @default.
- W2308382434 countsByYear W23083824342019 @default.
- W2308382434 countsByYear W23083824342020 @default.
- W2308382434 countsByYear W23083824342021 @default.
- W2308382434 countsByYear W23083824342022 @default.
- W2308382434 countsByYear W23083824342023 @default.
- W2308382434 crossrefType "journal-article" @default.
- W2308382434 hasAuthorship W2308382434A5008413606 @default.
- W2308382434 hasAuthorship W2308382434A5030152455 @default.
- W2308382434 hasAuthorship W2308382434A5031973253 @default.
- W2308382434 hasAuthorship W2308382434A5041307931 @default.
- W2308382434 hasAuthorship W2308382434A5084225297 @default.
- W2308382434 hasBestOaLocation W23083824341 @default.
- W2308382434 hasConcept C118131993 @default.
- W2308382434 hasConcept C118487528 @default.
- W2308382434 hasConcept C126322002 @default.
- W2308382434 hasConcept C1491633281 @default.
- W2308382434 hasConcept C163415756 @default.
- W2308382434 hasConcept C185592680 @default.
- W2308382434 hasConcept C2775888743 @default.
- W2308382434 hasConcept C2780942790 @default.
- W2308382434 hasConcept C55493867 @default.
- W2308382434 hasConcept C60870556 @default.
- W2308382434 hasConcept C71924100 @default.
- W2308382434 hasConceptScore W2308382434C118131993 @default.
- W2308382434 hasConceptScore W2308382434C118487528 @default.
- W2308382434 hasConceptScore W2308382434C126322002 @default.
- W2308382434 hasConceptScore W2308382434C1491633281 @default.
- W2308382434 hasConceptScore W2308382434C163415756 @default.
- W2308382434 hasConceptScore W2308382434C185592680 @default.
- W2308382434 hasConceptScore W2308382434C2775888743 @default.
- W2308382434 hasConceptScore W2308382434C2780942790 @default.
- W2308382434 hasConceptScore W2308382434C55493867 @default.
- W2308382434 hasConceptScore W2308382434C60870556 @default.
- W2308382434 hasConceptScore W2308382434C71924100 @default.
- W2308382434 hasIssue "2" @default.
- W2308382434 hasLocation W23083824341 @default.
- W2308382434 hasLocation W23083824342 @default.
- W2308382434 hasOpenAccess W2308382434 @default.
- W2308382434 hasPrimaryLocation W23083824341 @default.
- W2308382434 hasRelatedWork W1774678331 @default.
- W2308382434 hasRelatedWork W1981537118 @default.
- W2308382434 hasRelatedWork W1985382259 @default.
- W2308382434 hasRelatedWork W2092558545 @default.
- W2308382434 hasRelatedWork W2368747855 @default.
- W2308382434 hasRelatedWork W30551261 @default.
- W2308382434 hasRelatedWork W3142368482 @default.
- W2308382434 hasRelatedWork W4250894260 @default.
- W2308382434 hasRelatedWork W566002373 @default.
- W2308382434 hasRelatedWork W3031535749 @default.
- W2308382434 hasVolume "42" @default.
- W2308382434 isParatext "false" @default.
- W2308382434 isRetracted "false" @default.
- W2308382434 magId "2308382434" @default.
- W2308382434 workType "article" @default.