FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2308449061> ?p ?o ?g. }

• W2308449061 endingPage "31" @default.
• W2308449061 startingPage "23" @default.
• W2308449061 abstract "Recent data demonstrate that chronic exposure of Caenorhabditis elegans (C. elegans) to a high-use glyphosate-containing herbicide, Touchdown (TD), potentially damages the adult nervous system. It is unknown, however, whether unhatched worms exposed to TD during the egg stage show abnormal neurodevelopment post-hatching. Therefore, we investigated whether early treatment with TD leads to aberrant neuronal or neurite development in C. elegans. Studies were completed in three different worm strains with green fluorescent protein (GFP)-tagged neurons to facilitate visual neuronal assessment. Initially, eggs from C. elegans with all neurons tagged with GFP were chronically exposed to TD. Visual inspection suggested decreased neurite projections associated with ventral nerve cord neurons. Data analysis showed a statistically significant decrease in overall green pixel numbers at the fourth larval (L4) stage (*p < 0.05). We further investigated whether specific neuronal populations were preferentially vulnerable to TD by treating eggs from worms that had all dopaminergic (DAergic) or γ-aminobutyric acid (GABAergic) neurons tagged with GFP. As before, green pixel number associated with these discrete neuronal populations was analyzed at multiple larval stages. Data analysis indicated statistically significant decreases in pixel number associated with DAergic, but not GABAergic, neurons (***p < 0.001) at all larval stages. Finally, statistically significant decreases (at the first larval stage, L1) or increases (at the fourth larval stage, L4) in superoxide levels, a developmental signaling molecule, were detected (*p < 0.05). These data suggest that early exposure to TD may impair neuronal development, perhaps through superoxide perturbation. Since toxic insults during development may late render individuals more vulnerable to neurodegenerative diseases in adulthood, these studies provide some of the first evidence in this model organism that early exposure to TD may adversely affect the developing nervous system." @default.
• W2308449061 created "2016-06-24" @default.
• W2308449061 creator A5009260651 @default.
• W2308449061 creator A5016756019 @default.
• W2308449061 creator A5039775845 @default.
• W2308449061 creator A5051418573 @default.
• W2308449061 creator A5051712425 @default.
• W2308449061 creator A5081986811 @default.
• W2308449061 date "2016-05-01" @default.
• W2308449061 modified "2023-09-23" @default.
• W2308449061 title "Exposure of C. elegans eggs to a glyphosate-containing herbicide leads to abnormal neuronal morphology" @default.
• W2308449061 cites W147799240 @default.
• W2308449061 cites W1484999790 @default.
• W2308449061 cites W1542007198 @default.
• W2308449061 cites W1604729272 @default.
• W2308449061 cites W1970847183 @default.
• W2308449061 cites W1971383450 @default.
• W2308449061 cites W1975728052 @default.
• W2308449061 cites W1979562512 @default.
• W2308449061 cites W1986581387 @default.
• W2308449061 cites W1989942360 @default.
• W2308449061 cites W1997242730 @default.
• W2308449061 cites W2010556539 @default.
• W2308449061 cites W2016985488 @default.
• W2308449061 cites W2020028608 @default.
• W2308449061 cites W2024052509 @default.
• W2308449061 cites W2025449751 @default.
• W2308449061 cites W2029313416 @default.
• W2308449061 cites W2035111849 @default.
• W2308449061 cites W2056197134 @default.
• W2308449061 cites W2062198266 @default.
• W2308449061 cites W2070992087 @default.
• W2308449061 cites W2074456525 @default.
• W2308449061 cites W2076082769 @default.
• W2308449061 cites W2077817892 @default.
• W2308449061 cites W2080099105 @default.
• W2308449061 cites W2081748503 @default.
• W2308449061 cites W2091712128 @default.
• W2308449061 cites W2092189462 @default.
• W2308449061 cites W2093293956 @default.
• W2308449061 cites W2115989432 @default.
• W2308449061 cites W2116716062 @default.
• W2308449061 cites W2126941269 @default.
• W2308449061 cites W2126972806 @default.
• W2308449061 cites W2134236053 @default.
• W2308449061 cites W2135239355 @default.
• W2308449061 cites W2135657678 @default.
• W2308449061 cites W2138524649 @default.
• W2308449061 cites W2140991219 @default.
• W2308449061 cites W2143404726 @default.
• W2308449061 cites W2147373429 @default.
• W2308449061 cites W2149992333 @default.
• W2308449061 cites W2160433223 @default.
• W2308449061 cites W2160938187 @default.
• W2308449061 cites W2161219767 @default.
• W2308449061 cites W2163656090 @default.
• W2308449061 cites W2163849189 @default.
• W2308449061 cites W2171727894 @default.
• W2308449061 cites W2253724584 @default.
• W2308449061 cites W418495168 @default.
• W2308449061 cites W4246813496 @default.
• W2308449061 cites W4251401190 @default.
• W2308449061 cites W68854549 @default.
• W2308449061 doi "https://doi.org/10.1016/j.ntt.2016.03.002" @default.
• W2308449061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4884470" @default.
• W2308449061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27019975" @default.
• W2308449061 hasPublicationYear "2016" @default.
• W2308449061 type Work @default.
• W2308449061 sameAs 2308449061 @default.
• W2308449061 citedByCount "26" @default.
• W2308449061 countsByYear W23084490612017 @default.
• W2308449061 countsByYear W23084490612018 @default.
• W2308449061 countsByYear W23084490612019 @default.
• W2308449061 countsByYear W23084490612020 @default.
• W2308449061 countsByYear W23084490612021 @default.
• W2308449061 countsByYear W23084490612022 @default.
• W2308449061 countsByYear W23084490612023 @default.
• W2308449061 crossrefType "journal-article" @default.
• W2308449061 hasAuthorship W2308449061A5009260651 @default.
• W2308449061 hasAuthorship W2308449061A5016756019 @default.
• W2308449061 hasAuthorship W2308449061A5039775845 @default.
• W2308449061 hasAuthorship W2308449061A5051418573 @default.
• W2308449061 hasAuthorship W2308449061A5051712425 @default.
• W2308449061 hasAuthorship W2308449061A5081986811 @default.
• W2308449061 hasBestOaLocation W23084490612 @default.
• W2308449061 hasConcept C104317684 @default.
• W2308449061 hasConcept C105702510 @default.
• W2308449061 hasConcept C113246987 @default.
• W2308449061 hasConcept C142613039 @default.
• W2308449061 hasConcept C158944026 @default.
• W2308449061 hasConcept C169760540 @default.
• W2308449061 hasConcept C17077164 @default.
• W2308449061 hasConcept C173758957 @default.
• W2308449061 hasConcept C18903297 @default.
• W2308449061 hasConcept C202751555 @default.
• W2308449061 hasConcept C2777744765 @default.
• W2308449061 hasConcept C2778944004 @default.
• W2308449061 hasConcept C2779177108 @default.

• next