FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2308451738> ?p ?o ?g. }

• W2308451738 endingPage "e0152172" @default.
• W2308451738 startingPage "e0152172" @default.
• W2308451738 abstract "Obesity is a known risk factor for PDA and recent reports suggest obesity has a negative impact on clinical outcomes in patients with PDA. Pretreatment body mass index (BMI) and serum albumin (SA) have been shown to be associated with worse overall survival in patients with advanced and metastatic PDA. However, minimal data exists on the impact of BMI and SA on perioperative and long-term clinical outcomes in patients with early-stage resected PDA. Herein, we report on the impact of these variables on perioperative clinical outcomes, overall survival (OS) and disease free survival (DFS) in patients with resected PDA. With IRB approval, we evaluated 1,545 patients with PDA treated at a single institution from 2007-2013 and identified 106 patients who underwent upfront resection with curative intent. BMI and SA were calculated preoperatively and at the time of last clinical evaluation. Influence of preoperative BMI, SA, change in either variable, and influence of other clinical and pathologic variables on perioperative morbidity and mortality was assessed. The impact of these variables on DFS and OS was assessed with cox regression modeling and ANOVA. Actuarial estimates for DFS and OS were calculated using Kaplan-Meier methods. Median follow up time was 16 months (3-89). Mean age was 68 years. Median survival was 14 months (3-65) and median time to recurrence was 11 months (1-79). Length of hospital stay was associated with BMI (p = .023), change in BMI (p = .003) and SA (p = .004). Post-operative transfusion rate was associated with SA (p = .021). There was a strong correlation between BMI change and positive margin (p = .04) and lymph node status (p = .01). On multivariate analysis, change in SA (p = .03) and node positivity (p = .008) were associated with decreased DFS. Additionally, preoperative SA (p = .023), node positivity (p = .026) and poor differentiation (p = .045) were associated with worse OS on multivariate analysis. Low preoperative SA was associated with worse DFS and OS in patients with resected PDA. Lower BMI and SA were associated with longer post-operative hospital stay. Our study is one of the first to describe how pre-operative BMI and SA and post-operative changes in these variables impact clinical and perioperative outcomes. This data supports nutritional status and weight loss as predictors of outcome in resected pancreatic cancer patients and warrants further prospective investigation." @default.
• W2308451738 created "2016-06-24" @default.
• W2308451738 creator A5005658250 @default.
• W2308451738 creator A5011949620 @default.
• W2308451738 creator A5021340201 @default.
• W2308451738 creator A5024750927 @default.
• W2308451738 creator A5027206034 @default.
• W2308451738 creator A5027630636 @default.
• W2308451738 creator A5039815268 @default.
• W2308451738 creator A5078887745 @default.
• W2308451738 date "2016-03-25" @default.
• W2308451738 modified "2023-10-16" @default.
• W2308451738 title "Influence of Body Mass Index and Albumin on Perioperative Morbidity and Clinical Outcomes in Resected Pancreatic Adenocarcinoma" @default.
• W2308451738 cites W1532339742 @default.
• W2308451738 cites W1563040224 @default.
• W2308451738 cites W1575461655 @default.
• W2308451738 cites W1965943690 @default.
• W2308451738 cites W1969074752 @default.
• W2308451738 cites W1970087635 @default.
• W2308451738 cites W1989915262 @default.
• W2308451738 cites W1994179625 @default.
• W2308451738 cites W2008431672 @default.
• W2308451738 cites W2029014150 @default.
• W2308451738 cites W2035438838 @default.
• W2308451738 cites W2041487861 @default.
• W2308451738 cites W2043737378 @default.
• W2308451738 cites W2045901590 @default.
• W2308451738 cites W2048038826 @default.
• W2308451738 cites W2055807052 @default.
• W2308451738 cites W2066185056 @default.
• W2308451738 cites W2085674426 @default.
• W2308451738 cites W2104846685 @default.
• W2308451738 cites W2111525190 @default.
• W2308451738 cites W2116008558 @default.
• W2308451738 cites W2123467283 @default.
• W2308451738 cites W2132899214 @default.
• W2308451738 cites W2145280166 @default.
• W2308451738 cites W2152963742 @default.
• W2308451738 cites W2162821812 @default.
• W2308451738 cites W2169961966 @default.
• W2308451738 cites W2172292090 @default.
• W2308451738 cites W2219978888 @default.
• W2308451738 cites W2597571008 @default.
• W2308451738 doi "https://doi.org/10.1371/journal.pone.0152172" @default.
• W2308451738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4807776" @default.
• W2308451738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27015568" @default.
• W2308451738 hasPublicationYear "2016" @default.
• W2308451738 type Work @default.
• W2308451738 sameAs 2308451738 @default.
• W2308451738 citedByCount "40" @default.
• W2308451738 countsByYear W23084517382016 @default.
• W2308451738 countsByYear W23084517382017 @default.
• W2308451738 countsByYear W23084517382018 @default.
• W2308451738 countsByYear W23084517382019 @default.
• W2308451738 countsByYear W23084517382020 @default.
• W2308451738 countsByYear W23084517382021 @default.
• W2308451738 countsByYear W23084517382022 @default.
• W2308451738 countsByYear W23084517382023 @default.
• W2308451738 crossrefType "journal-article" @default.
• W2308451738 hasAuthorship W2308451738A5005658250 @default.
• W2308451738 hasAuthorship W2308451738A5011949620 @default.
• W2308451738 hasAuthorship W2308451738A5021340201 @default.
• W2308451738 hasAuthorship W2308451738A5024750927 @default.
• W2308451738 hasAuthorship W2308451738A5027206034 @default.
• W2308451738 hasAuthorship W2308451738A5027630636 @default.
• W2308451738 hasAuthorship W2308451738A5039815268 @default.
• W2308451738 hasAuthorship W2308451738A5078887745 @default.
• W2308451738 hasBestOaLocation W23084517381 @default.
• W2308451738 hasConcept C126322002 @default.
• W2308451738 hasConcept C141071460 @default.
• W2308451738 hasConcept C2780221984 @default.
• W2308451738 hasConcept C31174226 @default.
• W2308451738 hasConcept C50382708 @default.
• W2308451738 hasConcept C511355011 @default.
• W2308451738 hasConcept C71924100 @default.
• W2308451738 hasConceptScore W2308451738C126322002 @default.
• W2308451738 hasConceptScore W2308451738C141071460 @default.
• W2308451738 hasConceptScore W2308451738C2780221984 @default.
• W2308451738 hasConceptScore W2308451738C31174226 @default.
• W2308451738 hasConceptScore W2308451738C50382708 @default.
• W2308451738 hasConceptScore W2308451738C511355011 @default.
• W2308451738 hasConceptScore W2308451738C71924100 @default.
• W2308451738 hasIssue "3" @default.
• W2308451738 hasLocation W23084517381 @default.
• W2308451738 hasLocation W23084517382 @default.
• W2308451738 hasLocation W23084517383 @default.
• W2308451738 hasLocation W23084517384 @default.
• W2308451738 hasLocation W23084517385 @default.
• W2308451738 hasOpenAccess W2308451738 @default.
• W2308451738 hasPrimaryLocation W23084517381 @default.
• W2308451738 hasRelatedWork W2030364932 @default.
• W2308451738 hasRelatedWork W2047967234 @default.
• W2308451738 hasRelatedWork W2327556405 @default.
• W2308451738 hasRelatedWork W2349210304 @default.
• W2308451738 hasRelatedWork W2352247659 @default.
• W2308451738 hasRelatedWork W2354785620 @default.
• W2308451738 hasRelatedWork W2375359181 @default.
• W2308451738 hasRelatedWork W2439875401 @default.

• next