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• W2308483384 endingPage "e000386" @default.
• W2308483384 startingPage "e000386" @default.
• W2308483384 abstract "<h3>Objective</h3> Female sex is considered a risk factor for adverse outcomes following isolated coronary artery bypass graft (CABG) surgery. We assessed the association between sex and short-term mortality following isolated CABG, and estimated the ‘excess’ deaths occurring in women. <h3>Methods</h3> Short-term mortality was investigated in 13 327 consecutive isolated CABG patients in North Texas between January 2008 and December 2012. The association between sex and CABG short-term mortality, and the excess deaths among women were assessed via a propensity-adjusted (by Society of Thoracic Surgeons-recognised risk factors) generalised estimating equations model approach. <h3>Results</h3> Short-term mortality was significantly higher in women than men (adjusted OR=1.39; 95% CI 1.04 to 1.86; p=0.027). This significantly greater risk translates into 35 ‘excess’ deaths among women included in this study (>10% of the total 343 deaths in the study cohort) and into 392 ‘excess’ deaths among the ∼40 000 women undergoing isolated CABG in the USA each year. <h3>Conclusions</h3> The higher risk associated with female sex lead to 35 ‘excess’ deaths in women in this study cohort (over 10% of the total deaths) and to 392 ‘excess’ deaths among women undergoing isolated CABG in the USA each year. Further research is needed to assess the causal mechanisms underlying this sex-related difference. Results of such work could inform the development and implementation of sex-specific treatment and management strategies to reduce women9s mortality following CABG. Based on our results, if such work brought women9s short-term mortality into line with men9s, total short-term mortality could be reduced by up to 10%." @default.
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• W2308483384 date "2016-03-01" @default.
• W2308483384 modified "2023-09-26" @default.
• W2308483384 title "Excess short-term mortality in women after isolated coronary artery bypass graft surgery" @default.
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• W2308483384 doi "https://doi.org/10.1136/openhrt-2015-000386" @default.
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