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• W2308483780 endingPage "1079" @default.
• W2308483780 startingPage "1069" @default.
• W2308483780 abstract "Adaptation to stress by eukaryotic pathogens is often accompanied by a transition in cellular morphology. The human fungal pathogen Cryptococcus neoformans is known to switch between the yeast and the filamentous form in response to amoebic predation or during mating. As in the classic dimorphic fungal pathogens, the morphotype is associated with the ability of cryptococci to infect various hosts. Many cryptococcal factors and environmental stimuli, including pheromones (small peptides) and nutrient limitation, are known to induce the yeast-to-hypha transition. We recently discovered that secreted matricellular proteins could also act as intercellular signals to promote the yeast-to-hypha transition. Here we show that the secreted acyl coenzyme A (acyl-CoA)-binding protein Acb1 plays an important role in enhancing this morphotype transition. Acb1 does not possess a signal peptide. Its extracellular secretion and, consequently, its function in filamentation are dependent on an unconventional GRASP (Golgi reassembly stacking protein)-dependent secretion pathway. Surprisingly, intracellular recruitment of Acb1 to the secretory vesicles is independent of Grasp. In addition to Acb1, Grasp possibly controls the secretion of other cargos, because the graspΔ mutant, but not the acb1Δ mutant, is defective in capsule production and macrophage phagocytosis. Nonetheless, Acb1 is likely the major or the sole effector of Grasp in terms of filamentation. Furthermore, we found that the key residue of Acb1 for acyl binding, Y80, is critical for the proper subcellular localization and secretion of Acb1 and for cryptococcal morphogenesis." @default.
• W2308483780 created "2016-06-24" @default.
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• W2308483780 creator A5022430782 @default.
• W2308483780 creator A5040113983 @default.
• W2308483780 creator A5064395342 @default.
• W2308483780 date "2016-02-15" @default.
• W2308483780 modified "2023-10-15" @default.
• W2308483780 title "Secreted Acb1 Contributes to the Yeast-to-Hypha Transition in Cryptococcus neoformans" @default.
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• W2308483780 cites W1731585115 @default.
• W2308483780 cites W1872803163 @default.
• W2308483780 cites W1949079829 @default.
• W2308483780 cites W1966182526 @default.
• W2308483780 cites W1968182352 @default.
• W2308483780 cites W1988206655 @default.
• W2308483780 cites W1988750758 @default.
• W2308483780 cites W1993006442 @default.
• W2308483780 cites W1993690543 @default.
• W2308483780 cites W1997469380 @default.
• W2308483780 cites W2000373375 @default.
• W2308483780 cites W2001555960 @default.
• W2308483780 cites W2001999711 @default.
• W2308483780 cites W2003092273 @default.
• W2308483780 cites W2005505835 @default.
• W2308483780 cites W2010197844 @default.
• W2308483780 cites W2016599296 @default.
• W2308483780 cites W2018636088 @default.
• W2308483780 cites W2020433831 @default.
• W2308483780 cites W2026924192 @default.
• W2308483780 cites W2027712573 @default.
• W2308483780 cites W2034145518 @default.
• W2308483780 cites W2038581960 @default.
• W2308483780 cites W2040468875 @default.
• W2308483780 cites W2040942663 @default.
• W2308483780 cites W2041675379 @default.
• W2308483780 cites W2047667571 @default.
• W2308483780 cites W2054976550 @default.
• W2308483780 cites W2055298300 @default.
• W2308483780 cites W2061969838 @default.
• W2308483780 cites W2069573236 @default.
• W2308483780 cites W2075043312 @default.
• W2308483780 cites W2075075969 @default.
• W2308483780 cites W2078734228 @default.
• W2308483780 cites W2079513681 @default.
• W2308483780 cites W2079928619 @default.
• W2308483780 cites W2080359769 @default.
• W2308483780 cites W2082120419 @default.
• W2308483780 cites W2082372749 @default.
• W2308483780 cites W2090610760 @default.
• W2308483780 cites W2092441027 @default.
• W2308483780 cites W2093236017 @default.
• W2308483780 cites W2095699986 @default.
• W2308483780 cites W2102940990 @default.
• W2308483780 cites W2105976996 @default.
• W2308483780 cites W2108705900 @default.
• W2308483780 cites W2117903782 @default.
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• W2308483780 cites W2132656747 @default.
• W2308483780 cites W2135671048 @default.
• W2308483780 cites W2136651521 @default.
• W2308483780 cites W2136773542 @default.
• W2308483780 cites W2140291146 @default.
• W2308483780 cites W2141800898 @default.
• W2308483780 cites W2142045101 @default.
• W2308483780 cites W2149652604 @default.
• W2308483780 cites W2151840748 @default.
• W2308483780 cites W2154239618 @default.
• W2308483780 cites W2157336637 @default.
• W2308483780 cites W2158375075 @default.
• W2308483780 cites W2159141936 @default.
• W2308483780 cites W2160367765 @default.
• W2308483780 cites W2164604815 @default.
• W2308483780 cites W2166939812 @default.
• W2308483780 cites W2172895953 @default.
• W2308483780 cites W2192071399 @default.
• W2308483780 cites W2242477415 @default.
• W2308483780 cites W2312534394 @default.
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• W2308483780 doi "https://doi.org/10.1128/aem.03691-15" @default.
• W2308483780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4751841" @default.
• W2308483780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26637591" @default.
• W2308483780 hasPublicationYear "2016" @default.
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