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• W2308521180 abstract "Background: Fish oil supplementation has been shown to attenuate hyperpnea- and exercise-induced bronchoconstriction. In vitro studies suggest that the omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA), rather than eicosapentaenoic acid, may be the potent component of fish oil. Objective: Therefore, the main aim of this study was to determine whether DHA supplementation can attenuate hyperpneainduced bronchoconstriction (HIB) and airway inflammation in adults with asthma compared to placebo. Methods: Nine subjects (aged 18-30 years) with asthma and HIB participated in a randomized, double-blind, placebo-controlled crossover trial where they received either 4.0 g of DHA or placebo capsules for 3 weeks. Following a 2-week washout phase, subjects then received the opposite supplement for 3 weeks. Subjects were tested in a laboratory following an initial 2-week run-in phase and after each supplementation phase. Each time, bronchoprovocation was elicited with eucapnic voluntary hyperventilation (EVH), a surrogate for an exercise challenge. Prior to and following the EVH challenge, pulmonary function, exhaled breath condensate (EBC) pH, and EBC concentrations of 8-isoprostane and the DHA metabolites 17Shydroxydocosahexaenoic acid and protectin D1 were measured. This study was registered at clinicaltrials.gov (study # NCT01200446). Results: Nine subjects completed the crossover design protocol without any adverse effects. There were no significant changes (p > 0.05) in any variables measured (i.e., percent change in forced expiratory volume-1-sec, EBC pH, 8-isoprostane, protectin D1 and 17S-hydroxydocosahexaenoic acid) among the pre-supplementation, placebo, and DHA tests. The effect size (�…2) for the maximum percent change in FEV1 was 0.08. Conclusion: The data indicate that supplementation with 4.0 g of DHA for 3 weeks does not attenuate HIB or airway inflammation in asthmatic subjects compared to baseline or placebo. Variations in study design, including time course, dose," @default.
• W2308521180 created "2016-06-24" @default.
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• W2308521180 date "2013-04-22" @default.
• W2308521180 modified "2023-09-26" @default.
• W2308521180 title "Randomized Cross-Over Controlled Pilot Study of Docosahexaenoic Acid Supplementation on Airway Inflammation and Hyperpnea-Induced Bronchoconstriction in Adults with Asthma" @default.
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