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• W2308595859 abstract "This study investigates the effects of tonic thyroxine (T4) release via implanted pellets on standard metabolic rate (SMR), heart and liver masses, and selected intermediary metabolic enzymes in field-active lizards, Sceloporus undulatus. Plasma T4 was elevated within physiologically realistic levels to 22.7 ± 3.03 ng/mL (mean ± SE) versus 12.9 ± 2.44 in the same animals prior to implantation and 7.7 ± 1.45 ng/mL in untreated lizards captured concurrently. However, plasma T3 was not changed significantly (2.3 ± 0.39[ untreated] vs. 1.8 ± 0.22 ng/mL [experimental]; P = 0.231). Standard metabolic rate at 35° C was 55% higher (P = 0.040) in T4-implanted lizards, and plasma T4 was significantly correlated with SMR in this group (r² = 0.595; P = 0.003). Liver mass was 16% lower (P < 0.001) and heart mass was 9% higher (P = 0.045) in T4-implanted than in untreated lizards. Hepatic citrate synthase activity was increased significantly by T4 (13 ± 0 4 us. 15 ± 0.4 U/ g at 35° C[ P < 0.001]). Total citrate synthase activity (i.e., mass-specific activity X organ mass) was unchanged in liver (P = 0.552) and was significantly increased by T4 in heart (P = 0.050). Pyruvate kinase activity was increased by T4 in liver (20 ± 1.5 vs. 275 ± 1.0 U/g at 35° C[P < 0.001]), heart (378 ± 15.9 vs. 422 ± 10.3 [ P = 0.008]), and mixed-fiber skeletal muscle (1,062 ± 44.9 vs. 1,223 ± 39.0 [P = 0.039]). Hepatic cytosolic α-glycerophosphate dehydrogenase activity (cyt. α-GPDH) was reduced by T4 (82 ± 2.5 vs. 65 ± 2. 6 U/g at 35° C[ P = 0.001]). Total pyruvate kinase and total cyt. α-GPDH responded in parallel with their respective mass-specific activities. The present data suggest that T4 itself may have unexpectedly high physiological activity in lizards. The observed physiological responses to exogenous T4 suggest a T4-induced increment in exercise capacities infield-active S. undulatus and indicate that field experimentation is a feasible component of further efforts to clarify physiological responses to thyroid hormones in lizards. The importance of these invasive field experiments is underscored by comparisons of present data with other studies, a comparison that indicates suppression of physiological responsiveness to T4 in captive lizards." @default.
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• W2308595859 title "Effects of Thyroxine on Standard Metabolic Rate and Selected Intermediary Metabolic Enzymes in Field-Active Lizards Sceloporus undulatus" @default.
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• W2308595859 doi "https://doi.org/10.1086/physzool.63.3.30156231" @default.
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