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- W2308646456 abstract "Alzheimer’s disease (AD) is an age-related, neurodegenerative disorder characterized by cognitive impairment with memory loss, extracellular amyloid beta (Aβ) peptides aggregation, and intracellular hyper-phosphorylated tau neurofibrillary tangles (NFT) accumulation. Although the 5-lipoxygenase (5LO) protein enzyme is well known as an important modulators of oxidation and inflammation, recent work has highlighted the new hypothesis that this pathway may play a direct role in AD pathogenesis. In this review article, we will discuss how the 5LO via the γ-secretase influences Aβ peptides formation, and other molecular pathologies including neuroinflammation, synaptic integrity, and cognitive functions, and provide an assessment of how targeting this protein could lead to novel therapeutics for AD and other related neurodegenerative disorders." @default.
- W2308646456 created "2016-06-24" @default.
- W2308646456 creator A5066538322 @default.
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- W2308646456 date "2016-09-01" @default.
- W2308646456 modified "2023-10-18" @default.
- W2308646456 title "The 5-Lipoxygenase as modulator of Alzheimer’s γ-secretase and therapeutic target" @default.
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- W2308646456 doi "https://doi.org/10.1016/j.brainresbull.2016.03.010" @default.
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