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- W2308651192 abstract "This study was designed to clarify the mechanism of the inhibitory action of a nitric oxide (NO) donor, 3-morpholino-sydnonimine (SIN-1), on contraction, cytosolic level and ionic currents in guinea-pig ileum. SIN-1 inhibited 25 mM KCl- or histamine contraction in a concentration-dependent manner. SIN-1 reduced both the 25 mM KCl- and the histamine-stimulated increases in muscle tension in parallel with decreased Using the patch clamp technique with a holding potential of -60 mV, SIN-1 decreased peak Ba currents by (n=6) when voltage was stepped from -60 mV to +10 mV and this effect was blocked by ODQ a soluble guanylyl cyclase inhibitor. Cu/Zn SOD (100 U/ml), the free radical scavenger, had little effect on basal and SIN-1 inhibited peak by (n=5) in the presence of Cu/Zn SOD. In a cell clamped at a holding-potential of -40 mV, application of histamine induced an inward current. The histamine-induced inward current was markedly and reversibly inhibited by SIN-1, and this effect was abolished by ODQ In addition, SIN-1 markedly increased the depolarization-activated outward currents in the all potential ranges. We concluded that SIN-1 inhibits smooth muscle contraction mainly by decreasing resulted from the inhibition of L-type channels and the inhibition of nonselective cation currents and/or by the activation of currents via a cGMP-dependent pathway." @default.
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- W2308651192 date "2000-01-01" @default.
- W2308651192 modified "2023-09-30" @default.
- W2308651192 title "The effect of NO donor on contraction, cytosolic Ca^ level and ionic currents in guinea pig ileal smooth muscle" @default.
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