Matches in SemOpenAlex for { <https://semopenalex.org/work/W2308661534> ?p ?o ?g. }
- W2308661534 endingPage "5883" @default.
- W2308661534 startingPage "5874" @default.
- W2308661534 abstract "We investigate the relationship between the inherent secondary structure and aggregation propensity of peptides containing chameleon sequences (i.e., sequences that can adopt either α or β structure depending on context) using a combination of replica exchange molecular dynamics simulations, ion-mobility mass spectrometry, circular dichroism, and transmission electron microscopy. We focus on an eight-residue long chameleon sequence that can adopt an α-helical structure in the context of the iron-binding protein from Bacillus anthracis (PDB id 1JIG) and a β-strand in the context of the baculovirus P35 protein (PDB id 1P35). We show that the isolated chameleon sequence is intrinsically disordered, interconverting between α-helical and β-rich conformations. The inherent conformational plasticity of the sequence can be constrained by addition of flanking residues with a given secondary structure propensity. Intriguingly, we show that the chameleon sequence with helical flanking residues aggregates rapidly into fibrils, whereas the chameleon sequence with flanking residues that favor β-conformations has weak aggregation propensity. This work sheds new insights into the possible role of α-helical intermediates in fibril formation." @default.
- W2308661534 created "2016-06-24" @default.
- W2308661534 creator A5003417936 @default.
- W2308661534 creator A5004382973 @default.
- W2308661534 creator A5017314590 @default.
- W2308661534 creator A5033847316 @default.
- W2308661534 creator A5034511172 @default.
- W2308661534 creator A5086969690 @default.
- W2308661534 date "2016-04-01" @default.
- W2308661534 modified "2023-10-18" @default.
- W2308661534 title "Aggregation of Chameleon Peptides: Implications of α-Helicity in Fibril Formation" @default.
- W2308661534 cites W1019196253 @default.
- W2308661534 cites W1580998020 @default.
- W2308661534 cites W1596655886 @default.
- W2308661534 cites W1609438619 @default.
- W2308661534 cites W1665864650 @default.
- W2308661534 cites W1966442040 @default.
- W2308661534 cites W1971356093 @default.
- W2308661534 cites W1971419973 @default.
- W2308661534 cites W1971804606 @default.
- W2308661534 cites W1972535964 @default.
- W2308661534 cites W1975041039 @default.
- W2308661534 cites W1976545437 @default.
- W2308661534 cites W1976727092 @default.
- W2308661534 cites W1979446703 @default.
- W2308661534 cites W1980125299 @default.
- W2308661534 cites W1980138515 @default.
- W2308661534 cites W1981396716 @default.
- W2308661534 cites W1982675913 @default.
- W2308661534 cites W1988569972 @default.
- W2308661534 cites W1989386714 @default.
- W2308661534 cites W1992979903 @default.
- W2308661534 cites W1994277047 @default.
- W2308661534 cites W1994520296 @default.
- W2308661534 cites W1994560730 @default.
- W2308661534 cites W2000830335 @default.
- W2308661534 cites W2005631746 @default.
- W2308661534 cites W2008342614 @default.
- W2308661534 cites W2008708467 @default.
- W2308661534 cites W2010622646 @default.
- W2308661534 cites W2010807142 @default.
- W2308661534 cites W2018769240 @default.
- W2308661534 cites W2019408667 @default.
- W2308661534 cites W2022756726 @default.
- W2308661534 cites W2028726006 @default.
- W2308661534 cites W2029667189 @default.
- W2308661534 cites W2032487213 @default.
- W2308661534 cites W2036738021 @default.
- W2308661534 cites W2039011144 @default.
- W2308661534 cites W2040809566 @default.
- W2308661534 cites W2041250499 @default.
- W2308661534 cites W2046379303 @default.
- W2308661534 cites W2052033610 @default.
- W2308661534 cites W2055244876 @default.
- W2308661534 cites W2058524575 @default.
- W2308661534 cites W2058651019 @default.
- W2308661534 cites W2063328932 @default.
- W2308661534 cites W2069429456 @default.
- W2308661534 cites W2076201821 @default.
- W2308661534 cites W2087256677 @default.
- W2308661534 cites W2088594413 @default.
- W2308661534 cites W2089258285 @default.
- W2308661534 cites W2090615391 @default.
- W2308661534 cites W2090797167 @default.
- W2308661534 cites W2091474459 @default.
- W2308661534 cites W2093645477 @default.
- W2308661534 cites W2093861673 @default.
- W2308661534 cites W2094875206 @default.
- W2308661534 cites W2099092270 @default.
- W2308661534 cites W2102470476 @default.
- W2308661534 cites W2105277973 @default.
- W2308661534 cites W2105607576 @default.
- W2308661534 cites W2109710470 @default.
- W2308661534 cites W2110515879 @default.
- W2308661534 cites W2117537971 @default.
- W2308661534 cites W2120836715 @default.
- W2308661534 cites W2128547681 @default.
- W2308661534 cites W2141128950 @default.
- W2308661534 cites W2149060580 @default.
- W2308661534 cites W2149478284 @default.
- W2308661534 cites W2161379168 @default.
- W2308661534 cites W2163210644 @default.
- W2308661534 cites W2166848357 @default.
- W2308661534 cites W2167904135 @default.
- W2308661534 cites W2169693347 @default.
- W2308661534 cites W2188374540 @default.
- W2308661534 cites W2230658567 @default.
- W2308661534 cites W2320400235 @default.
- W2308661534 cites W2326957669 @default.
- W2308661534 cites W2327409223 @default.
- W2308661534 cites W2329027920 @default.
- W2308661534 cites W2515706561 @default.
- W2308661534 cites W2963358781 @default.
- W2308661534 doi "https://doi.org/10.1021/acs.jpcb.6b00830" @default.
- W2308661534 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4936924" @default.
- W2308661534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27001160" @default.
- W2308661534 hasPublicationYear "2016" @default.
- W2308661534 type Work @default.