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• W2308670129 endingPage "2698" @default.
• W2308670129 startingPage "2690" @default.
• W2308670129 abstract "FIP-gat, an immunomodulatory protein isolated from Ganoderma atrum, is a new member of the FIP family. Little is known, however, about its expressional properties and antitumor activities. It was availably expressed in Escherichia coli with a total yield of 29.75 mg/L. The migration of recombinant FIP-gat (rFIP-gat) on SDS-PAGE corresponded to the predicted molecular mass, and the band was correctly detected by a specific antibody. To characterize the direct effects of rFIP-gat on MDA-MB-231 breast cancer cells, MDA-MB-231 cells were treated with different concentrations of rFIP-gat in vitro; the results showed that this protein could reduce cell viability dose-dependently with a median inhibitory concentration (IC50) of 9.96 μg/mL and agglutinate the MDA-MB-231 cells at a concentration as low as 5 μg/mL. Furthermore, FIP-gat at a concentration of 10 μg/mL can induce significant growth inhibition and cell death in MDA-MB-231 cells. Notably, FIP-gat treatment triggers significant cell cycle arrest at the G1/S transition and pronounced increase in apoptotic cell population. Molecular assays based on microarray and real-time PCR further revealed the potential mechanisms encompassing growth arrest, apoptosis, and autophagy underlying the phenotypic effects." @default.
• W2308670129 created "2016-06-24" @default.
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• W2308670129 date "2016-03-24" @default.
• W2308670129 modified "2023-09-25" @default.
• W2308670129 title "Recombinant FIP-gat, a Fungal Immunomodulatory Protein from <i>Ganoderma atrum</i>, Induces Growth Inhibition and Cell Death in Breast Cancer Cells" @default.
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• W2308670129 doi "https://doi.org/10.1021/acs.jafc.6b00539" @default.
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• W2308670129 hasPublicationYear "2016" @default.
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