Matches in SemOpenAlex for { <https://semopenalex.org/work/W2308676181> ?p ?o ?g. }
- W2308676181 endingPage "7" @default.
- W2308676181 startingPage "7" @default.
- W2308676181 abstract "Sialoadhesin (Sn) is a surface receptor expressed on a subset of macrophages in steady state conditions. During inflammation and diseases, Sn is highly upregulated on macrophages and blood monocytes. Therefore, therapies using monoclonal antibodies (mAbs) to target Sn-positive (Sn+) cells are a potential strategy for targeted treatment. It has been shown that Sn internalizes after binding with a mAb, though it is not clear whether this is species-specific. In this study, new Sn-specific mAbs were developed and analyzed for cross-reactivity between species. In addition, the newly developed mAbs were compared to mAbs used in previous research for their epitope recognition and other Sn-specific characteristics. Both species-specific and cross-reactive antibodies could be identified. Furthermore, sialic acid-binding of red blood cells (RBC) could be inhibited with mAbs recognizing different epitopes and all mAb showed internalization of Sn. The newly developed mAbs can be used as novel tools for Sn research and further analysis of Sn internalization in different species." @default.
- W2308676181 created "2016-06-24" @default.
- W2308676181 creator A5001453932 @default.
- W2308676181 creator A5006674841 @default.
- W2308676181 creator A5008950728 @default.
- W2308676181 creator A5012992425 @default.
- W2308676181 creator A5013501595 @default.
- W2308676181 creator A5048127391 @default.
- W2308676181 creator A5052750090 @default.
- W2308676181 creator A5062878756 @default.
- W2308676181 creator A5078853174 @default.
- W2308676181 creator A5084892136 @default.
- W2308676181 date "2016-03-23" @default.
- W2308676181 modified "2023-09-23" @default.
- W2308676181 title "Development and Characterization of New Species Cross-Reactive Anti-Sialoadhesin Monoclonal Antibodies" @default.
- W2308676181 cites W1521669126 @default.
- W2308676181 cites W16780934 @default.
- W2308676181 cites W1689607850 @default.
- W2308676181 cites W1851859199 @default.
- W2308676181 cites W1912051574 @default.
- W2308676181 cites W1965657165 @default.
- W2308676181 cites W1971907885 @default.
- W2308676181 cites W1977012724 @default.
- W2308676181 cites W1979372191 @default.
- W2308676181 cites W1981160943 @default.
- W2308676181 cites W1984642900 @default.
- W2308676181 cites W1992174226 @default.
- W2308676181 cites W1992291725 @default.
- W2308676181 cites W2006518810 @default.
- W2308676181 cites W2007126729 @default.
- W2308676181 cites W2018083694 @default.
- W2308676181 cites W2019206924 @default.
- W2308676181 cites W2031102253 @default.
- W2308676181 cites W2033388004 @default.
- W2308676181 cites W2035871823 @default.
- W2308676181 cites W2044086145 @default.
- W2308676181 cites W2044425027 @default.
- W2308676181 cites W2054094621 @default.
- W2308676181 cites W2060734265 @default.
- W2308676181 cites W2062923968 @default.
- W2308676181 cites W2063424211 @default.
- W2308676181 cites W2069343409 @default.
- W2308676181 cites W2069411071 @default.
- W2308676181 cites W2075853683 @default.
- W2308676181 cites W2083337775 @default.
- W2308676181 cites W2087143668 @default.
- W2308676181 cites W2096406595 @default.
- W2308676181 cites W2108462881 @default.
- W2308676181 cites W2110820637 @default.
- W2308676181 cites W2115969448 @default.
- W2308676181 cites W2118075416 @default.
- W2308676181 cites W2121213570 @default.
- W2308676181 cites W2122264549 @default.
- W2308676181 cites W2145322488 @default.
- W2308676181 cites W2149103331 @default.
- W2308676181 cites W2154872900 @default.
- W2308676181 cites W2157365336 @default.
- W2308676181 cites W2158299621 @default.
- W2308676181 cites W2164590227 @default.
- W2308676181 cites W2170657296 @default.
- W2308676181 cites W2207615056 @default.
- W2308676181 cites W2229440641 @default.
- W2308676181 cites W3142951069 @default.
- W2308676181 doi "https://doi.org/10.3390/antib5020007" @default.
- W2308676181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6698821" @default.
- W2308676181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31557988" @default.
- W2308676181 hasPublicationYear "2016" @default.
- W2308676181 type Work @default.
- W2308676181 sameAs 2308676181 @default.
- W2308676181 citedByCount "6" @default.
- W2308676181 countsByYear W23086761812017 @default.
- W2308676181 countsByYear W23086761812020 @default.
- W2308676181 countsByYear W23086761812022 @default.
- W2308676181 countsByYear W23086761812023 @default.
- W2308676181 crossrefType "journal-article" @default.
- W2308676181 hasAuthorship W2308676181A5001453932 @default.
- W2308676181 hasAuthorship W2308676181A5006674841 @default.
- W2308676181 hasAuthorship W2308676181A5008950728 @default.
- W2308676181 hasAuthorship W2308676181A5012992425 @default.
- W2308676181 hasAuthorship W2308676181A5013501595 @default.
- W2308676181 hasAuthorship W2308676181A5048127391 @default.
- W2308676181 hasAuthorship W2308676181A5052750090 @default.
- W2308676181 hasAuthorship W2308676181A5062878756 @default.
- W2308676181 hasAuthorship W2308676181A5078853174 @default.
- W2308676181 hasAuthorship W2308676181A5084892136 @default.
- W2308676181 hasBestOaLocation W23086761811 @default.
- W2308676181 hasConcept C139770010 @default.
- W2308676181 hasConcept C153911025 @default.
- W2308676181 hasConcept C159654299 @default.
- W2308676181 hasConcept C170493617 @default.
- W2308676181 hasConcept C185592680 @default.
- W2308676181 hasConcept C195616568 @default.
- W2308676181 hasConcept C203014093 @default.
- W2308676181 hasConcept C2780115458 @default.
- W2308676181 hasConcept C542903549 @default.
- W2308676181 hasConcept C55493867 @default.
- W2308676181 hasConcept C86803240 @default.
- W2308676181 hasConceptScore W2308676181C139770010 @default.