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- W230867730 abstract "5-(2-Chloroethyl)-4-methylthiazole is used in the synthesis of heminevrin ( I ) a drug used as a hypnotic, tranquilizer, and anticonvulsant [1]. In most cases, heminevrin is obtained by chlorination of 5-(2-hydroxyethyl)-4-methylthiazole (II) by thionyl chloride, with a target product yield of 40 85% [2 6]. The purpose of this work was to study the possibility of chlorinating II by phosphorus pentachloride. As is known, phosphorus pentachloride is sometimes inferior to thionyl chloride with respect to the chlorination of alcohols [7]. On the other hand, phosphorus pentaehloride is a more readily available reagent, which justified our purpose. The process of 5-(2-hydroxyethyl)-4-methylthiazole chlorination with phosphorus pentachloride can be described by the following two-stage scheme: CH3 ~====~CH, +PCls, Ni0,,_f ~ , CH2CH2OH -POCI3 S CH2CH2Cl" @default.
- W230867730 created "2016-06-24" @default.
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- W230867730 date "1999-01-01" @default.
- W230867730 modified "2023-09-23" @default.
- W230867730 title "DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY SYNTHESIS OF 5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE USING THE REACTION OF 5-(2-HYDROXYETHYL)-4-METHYLTHIAZOLE WITH PHOSPHORUS PENTACHLORIDE" @default.
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