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• W2308693772 abstract "Novel immunotherapies are increasingly being used to treat malignant melanoma. The use of such agents has been associated with triggering autoimmunity. However, there has been a paucity in reports of limbic encephalitis associated with these immunotherapies. Pembrolizumab, a monoclonal antibody against programmed cell death antigen (PD-1), is currently being trialled in the UK to treat malignant melanoma. We report a unique case of antibody-negative limbic encephalitis presenting 1 year after starting pembrolizumab, in the context of malignant melanoma. The patient presented with progressive cognitive decline. MRI of the brain revealed signal change within the limbic structures. Cerebrospinal fluid studies confirmed evidence of inflammation with raised white cell count and protein. We were able to prevent further progression of symptoms by stopping pembrolizumab and treating the patient instead with steroids. We advocate considering autoimmune neuroinflammation as a differential for neurological disorders presenting in patients receiving PD-1 antagonist treatment and immunotherapy in general." @default.
• W2308693772 created "2016-06-24" @default.
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• W2308693772 date "2016-03-23" @default.
• W2308693772 modified "2023-10-18" @default.
• W2308693772 title "Limbic encephalitis following immunotherapy against metastatic malignant melanoma" @default.
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• W2308693772 doi "https://doi.org/10.1136/bcr-2016-215012" @default.
• W2308693772 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4823556" @default.
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