Matches in SemOpenAlex for { <https://semopenalex.org/work/W2308781172> ?p ?o ?g. }
- W2308781172 abstract "miR-124, a brain-specific microRNA, was originally considered as a key regulator in neuronal differentiation and the development of the nervous system. Here we showed that miR-124 expression was suppressed in patients with epilepsy and rats after drug induced-seizures. Intrahippocampal administration of a miR-124 duplex led to alleviated seizure severity and prolonged onset latency in two rat models (pentylenetetrazole- and pilocarpine-induced seizures), while miR-124 inhibitor led to shortened onset latency in pilocarpine-induced seizure rat models. Moreover, the result of local field potentials (LFPs) records further demonstrated miR-124 may have anti-epilepsy function. Inhibition of neuronal firing by miR-124 was associated with the suppression of mEPSC, AMPAR- and NMDAR-mediated currents, which were accompanied by decreased surface expression of NMDAR. In addition, miR-124 injection resulted in decreased activity and expression of cAMP-response element-binding protein1 (CREB1). a key regulator in epileptogenesis. A dual-luciferase reporter assay was used to confirm that miR-124 targeted directly the 3′UTR of CREB1 gene and repressed the CREB1 expression in HEK293T cells. Immunoprecipitation studies confirmed that the CREB1 antibody effectively precipitated CREB1 and NMDAR1 but not GLUR1 from rat brain hippocampus. These results revealed a previously unknown function of miR-124 in neuronal excitability and provided a new insight into molecular mechanisms underlying epilepsy." @default.
- W2308781172 created "2016-06-24" @default.
- W2308781172 creator A5006583743 @default.
- W2308781172 creator A5011531318 @default.
- W2308781172 creator A5012162881 @default.
- W2308781172 creator A5035282947 @default.
- W2308781172 creator A5041690571 @default.
- W2308781172 creator A5046597133 @default.
- W2308781172 creator A5061942314 @default.
- W2308781172 creator A5068252474 @default.
- W2308781172 creator A5071177858 @default.
- W2308781172 creator A5071344179 @default.
- W2308781172 creator A5082643397 @default.
- W2308781172 creator A5084138890 @default.
- W2308781172 creator A5088092323 @default.
- W2308781172 date "2016-01-01" @default.
- W2308781172 modified "2023-10-12" @default.
- W2308781172 title "The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity" @default.
- W2308781172 cites W1965306643 @default.
- W2308781172 cites W1966758622 @default.
- W2308781172 cites W1968300632 @default.
- W2308781172 cites W1975439559 @default.
- W2308781172 cites W1975762084 @default.
- W2308781172 cites W1976463030 @default.
- W2308781172 cites W1978438606 @default.
- W2308781172 cites W1978931422 @default.
- W2308781172 cites W1983949013 @default.
- W2308781172 cites W1988749472 @default.
- W2308781172 cites W1992339350 @default.
- W2308781172 cites W1998117752 @default.
- W2308781172 cites W1998727354 @default.
- W2308781172 cites W2006869556 @default.
- W2308781172 cites W2009304543 @default.
- W2308781172 cites W2012614147 @default.
- W2308781172 cites W2017695960 @default.
- W2308781172 cites W2032954363 @default.
- W2308781172 cites W2033179944 @default.
- W2308781172 cites W2040191060 @default.
- W2308781172 cites W2045843363 @default.
- W2308781172 cites W2047819926 @default.
- W2308781172 cites W2051746294 @default.
- W2308781172 cites W2052985891 @default.
- W2308781172 cites W2058378735 @default.
- W2308781172 cites W2059222949 @default.
- W2308781172 cites W2070693418 @default.
- W2308781172 cites W2071890287 @default.
- W2308781172 cites W2072810552 @default.
- W2308781172 cites W2078264780 @default.
- W2308781172 cites W2079473624 @default.
- W2308781172 cites W2090183355 @default.
- W2308781172 cites W2094693123 @default.
- W2308781172 cites W2094767773 @default.
- W2308781172 cites W2095428415 @default.
- W2308781172 cites W2096755134 @default.
- W2308781172 cites W2102226828 @default.
- W2308781172 cites W2103946141 @default.
- W2308781172 cites W2108401127 @default.
- W2308781172 cites W2111890644 @default.
- W2308781172 cites W2111969156 @default.
- W2308781172 cites W2113659468 @default.
- W2308781172 cites W2119782911 @default.
- W2308781172 cites W2126436396 @default.
- W2308781172 cites W2132687986 @default.
- W2308781172 cites W2139296565 @default.
- W2308781172 cites W2139462364 @default.
- W2308781172 cites W2140116051 @default.
- W2308781172 cites W2147683366 @default.
- W2308781172 cites W2148042286 @default.
- W2308781172 cites W2148992111 @default.
- W2308781172 cites W2150497419 @default.
- W2308781172 cites W2151350973 @default.
- W2308781172 cites W2154909423 @default.
- W2308781172 cites W2156023352 @default.
- W2308781172 cites W2162674813 @default.
- W2308781172 cites W2166992424 @default.
- W2308781172 cites W2171260596 @default.
- W2308781172 cites W47694475 @default.
- W2308781172 doi "https://doi.org/10.1017/erm.2016.3" @default.
- W2308781172 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4836211" @default.
- W2308781172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26996991" @default.
- W2308781172 hasPublicationYear "2016" @default.
- W2308781172 type Work @default.
- W2308781172 sameAs 2308781172 @default.
- W2308781172 citedByCount "58" @default.
- W2308781172 countsByYear W23087811722016 @default.
- W2308781172 countsByYear W23087811722017 @default.
- W2308781172 countsByYear W23087811722018 @default.
- W2308781172 countsByYear W23087811722019 @default.
- W2308781172 countsByYear W23087811722020 @default.
- W2308781172 countsByYear W23087811722021 @default.
- W2308781172 countsByYear W23087811722022 @default.
- W2308781172 countsByYear W23087811722023 @default.
- W2308781172 crossrefType "journal-article" @default.
- W2308781172 hasAuthorship W2308781172A5006583743 @default.
- W2308781172 hasAuthorship W2308781172A5011531318 @default.
- W2308781172 hasAuthorship W2308781172A5012162881 @default.
- W2308781172 hasAuthorship W2308781172A5035282947 @default.
- W2308781172 hasAuthorship W2308781172A5041690571 @default.
- W2308781172 hasAuthorship W2308781172A5046597133 @default.
- W2308781172 hasAuthorship W2308781172A5061942314 @default.