FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2308796738> ?p ?o ?g. }

• W2308796738 endingPage "372" @default.
• W2308796738 startingPage "362" @default.
• W2308796738 abstract "Mammalian pancreatic β-cells play a pivotal role in development and glucose homeostasis through the production and secretion of insulin. Functional failure or decrease in β-cell number leads to type 2 diabetes (T2D). Despite the physiological importance of β-cells, the viability of β-cells is often challenged mainly due to its poor ability to adapt to their changing microenvironment. One of the factors that negatively affect β-cell viability is high concentration of free fatty acids (FFAs) such as palmitate. In this work, we demonstrated that Yes-associated protein (Yap1) is activated when β-cells are treated with palmitate. Our loss- and gain-of-function analyses using rodent insulinoma cell lines revealed that Yap1 suppresses palmitate-induced apoptosis in β-cells without regulating their proliferation. We also found that upon palmitate treatment, re-arrangement of F-actin mediates Yap1 activation. Palmitate treatment increases expression of one of the Yap1 target genes, connective tissue growth factor (CTGF). Our gain-of-function analysis with CTGF suggests CTGF may be the downstream factor of Yap1 in the protective mechanism against FFA-induced apoptosis." @default.
• W2308796738 created "2016-06-24" @default.
• W2308796738 creator A5013064881 @default.
• W2308796738 creator A5030803934 @default.
• W2308796738 creator A5058489235 @default.
• W2308796738 creator A5060068655 @default.
• W2308796738 creator A5080240822 @default.
• W2308796738 date "2016-03-22" @default.
• W2308796738 modified "2023-09-23" @default.
• W2308796738 title "Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival" @default.
• W2308796738 cites W1508050262 @default.
• W2308796738 cites W1790041644 @default.
• W2308796738 cites W1949381744 @default.
• W2308796738 cites W1970011751 @default.
• W2308796738 cites W1970420856 @default.
• W2308796738 cites W1970847396 @default.
• W2308796738 cites W1995573327 @default.
• W2308796738 cites W2001202251 @default.
• W2308796738 cites W2002800164 @default.
• W2308796738 cites W2006778392 @default.
• W2308796738 cites W2011818472 @default.
• W2308796738 cites W2014545259 @default.
• W2308796738 cites W2020468088 @default.
• W2308796738 cites W2026664054 @default.
• W2308796738 cites W2041888630 @default.
• W2308796738 cites W2049791689 @default.
• W2308796738 cites W2052311839 @default.
• W2308796738 cites W2052587867 @default.
• W2308796738 cites W2054180980 @default.
• W2308796738 cites W2062059848 @default.
• W2308796738 cites W2063779341 @default.
• W2308796738 cites W2066702528 @default.
• W2308796738 cites W2067184340 @default.
• W2308796738 cites W2075452487 @default.
• W2308796738 cites W2092328207 @default.
• W2308796738 cites W2093762253 @default.
• W2308796738 cites W2103396305 @default.
• W2308796738 cites W2121139915 @default.
• W2308796738 cites W2124059822 @default.
• W2308796738 cites W2126610675 @default.
• W2308796738 cites W2126700142 @default.
• W2308796738 cites W2145869245 @default.
• W2308796738 cites W2153599475 @default.
• W2308796738 cites W2154942574 @default.
• W2308796738 cites W2157559566 @default.
• W2308796738 cites W2159376228 @default.
• W2308796738 cites W2164026724 @default.
• W2308796738 cites W2164469233 @default.
• W2308796738 cites W2167978765 @default.
• W2308796738 cites W2171501785 @default.
• W2308796738 doi "https://doi.org/10.1007/s13238-016-0258-5" @default.
• W2308796738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4853318" @default.
• W2308796738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27000077" @default.
• W2308796738 hasPublicationYear "2016" @default.
• W2308796738 type Work @default.
• W2308796738 sameAs 2308796738 @default.
• W2308796738 citedByCount "15" @default.
• W2308796738 countsByYear W23087967382017 @default.
• W2308796738 countsByYear W23087967382018 @default.
• W2308796738 countsByYear W23087967382019 @default.
• W2308796738 countsByYear W23087967382020 @default.
• W2308796738 countsByYear W23087967382021 @default.
• W2308796738 countsByYear W23087967382022 @default.
• W2308796738 crossrefType "journal-article" @default.
• W2308796738 hasAuthorship W2308796738A5013064881 @default.
• W2308796738 hasAuthorship W2308796738A5030803934 @default.
• W2308796738 hasAuthorship W2308796738A5058489235 @default.
• W2308796738 hasAuthorship W2308796738A5060068655 @default.
• W2308796738 hasAuthorship W2308796738A5080240822 @default.
• W2308796738 hasBestOaLocation W23087967381 @default.
• W2308796738 hasConcept C104317684 @default.
• W2308796738 hasConcept C126322002 @default.
• W2308796738 hasConcept C134018914 @default.
• W2308796738 hasConcept C165220095 @default.
• W2308796738 hasConcept C170493617 @default.
• W2308796738 hasConcept C190283241 @default.
• W2308796738 hasConcept C2775960820 @default.
• W2308796738 hasConcept C2776828364 @default.
• W2308796738 hasConcept C2779306644 @default.
• W2308796738 hasConcept C2780219982 @default.
• W2308796738 hasConcept C2780631158 @default.
• W2308796738 hasConcept C55493867 @default.
• W2308796738 hasConcept C62112901 @default.
• W2308796738 hasConcept C71924100 @default.
• W2308796738 hasConcept C86339819 @default.
• W2308796738 hasConcept C86803240 @default.
• W2308796738 hasConcept C95444343 @default.
• W2308796738 hasConceptScore W2308796738C104317684 @default.
• W2308796738 hasConceptScore W2308796738C126322002 @default.
• W2308796738 hasConceptScore W2308796738C134018914 @default.
• W2308796738 hasConceptScore W2308796738C165220095 @default.
• W2308796738 hasConceptScore W2308796738C170493617 @default.
• W2308796738 hasConceptScore W2308796738C190283241 @default.
• W2308796738 hasConceptScore W2308796738C2775960820 @default.
• W2308796738 hasConceptScore W2308796738C2776828364 @default.
• W2308796738 hasConceptScore W2308796738C2779306644 @default.
• W2308796738 hasConceptScore W2308796738C2780219982 @default.
• W2308796738 hasConceptScore W2308796738C2780631158 @default.

• next