Matches in SemOpenAlex for { <https://semopenalex.org/work/W2308801214> ?p ?o ?g. }
- W2308801214 abstract "Long INterspersed Element-1 (LINE-1 or L1) retrotransposons form the only autonomously active family of transposable elements in humans. They are expressed and mobile in the germline, in embryonic stem cells and in the early embryo, but are silenced in most somatic tissues. Consistently, they play an important role in individual genome variations through insertional mutagenesis and sequence transduction, which occasionally lead to novel genetic diseases. In addition, they are reactivated in nearly half of the human epithelial cancers, contributing to tumor genome dynamics. The L1 element codes for two proteins, ORF1p and ORF2p, which are essential for its mobility. ORF1p is an RNA-binding protein with nucleic acid chaperone activity and ORF2p possesses endonuclease and reverse transcriptase activities. These proteins and the L1 RNA assemble into a ribonucleoprotein particle (L1 RNP), considered as the core of the retrotransposition machinery. The L1 RNP mediates the synthesis of new L1 copies upon cleavage of the target DNA and reverse transcription of the L1 RNA at the target site. The L1 element takes benefit of cellular host factors to complete its life cycle, however several cellular pathways also limit the cellular accumulation of L1 RNPs and their deleterious activities. Here, we review the known cellular host factors and pathways that regulate positively or negatively L1 retrotransposition at post-transcriptional level, in particular by interacting with the L1 machinery or L1 replication intermediates; and how they contribute to control L1 activity in somatic cells." @default.
- W2308801214 created "2016-06-24" @default.
- W2308801214 creator A5016607425 @default.
- W2308801214 creator A5091350606 @default.
- W2308801214 date "2016-03-07" @default.
- W2308801214 modified "2023-10-14" @default.
- W2308801214 title "Post-Transcriptional Control of LINE-1 Retrotransposition by Cellular Host Factors in Somatic Cells" @default.
- W2308801214 cites W1176330553 @default.
- W2308801214 cites W1509378838 @default.
- W2308801214 cites W1898603749 @default.
- W2308801214 cites W1944771638 @default.
- W2308801214 cites W1959325762 @default.
- W2308801214 cites W1965141089 @default.
- W2308801214 cites W1966477735 @default.
- W2308801214 cites W1974134624 @default.
- W2308801214 cites W1977771685 @default.
- W2308801214 cites W1978596306 @default.
- W2308801214 cites W1980126223 @default.
- W2308801214 cites W1980487637 @default.
- W2308801214 cites W1981915622 @default.
- W2308801214 cites W1986319478 @default.
- W2308801214 cites W1987332588 @default.
- W2308801214 cites W1987752798 @default.
- W2308801214 cites W1990015734 @default.
- W2308801214 cites W1991333931 @default.
- W2308801214 cites W1992007798 @default.
- W2308801214 cites W1992174688 @default.
- W2308801214 cites W1998983269 @default.
- W2308801214 cites W2000177767 @default.
- W2308801214 cites W2006699168 @default.
- W2308801214 cites W2007589425 @default.
- W2308801214 cites W2009503462 @default.
- W2308801214 cites W2010268348 @default.
- W2308801214 cites W2012169926 @default.
- W2308801214 cites W2015734897 @default.
- W2308801214 cites W2018177575 @default.
- W2308801214 cites W2019223429 @default.
- W2308801214 cites W2029884547 @default.
- W2308801214 cites W2032679533 @default.
- W2308801214 cites W2035120673 @default.
- W2308801214 cites W2035395679 @default.
- W2308801214 cites W2037794677 @default.
- W2308801214 cites W2037930474 @default.
- W2308801214 cites W2040741651 @default.
- W2308801214 cites W2041586254 @default.
- W2308801214 cites W2044602337 @default.
- W2308801214 cites W2045751302 @default.
- W2308801214 cites W2045807857 @default.
- W2308801214 cites W2046750712 @default.
- W2308801214 cites W2048560318 @default.
- W2308801214 cites W2053117901 @default.
- W2308801214 cites W2055705164 @default.
- W2308801214 cites W2056788947 @default.
- W2308801214 cites W2058235794 @default.
- W2308801214 cites W2059977521 @default.
- W2308801214 cites W2062238129 @default.
- W2308801214 cites W2064629259 @default.
- W2308801214 cites W2070807615 @default.
- W2308801214 cites W2072747624 @default.
- W2308801214 cites W2073098178 @default.
- W2308801214 cites W2075224242 @default.
- W2308801214 cites W2076699592 @default.
- W2308801214 cites W2076945600 @default.
- W2308801214 cites W2077053535 @default.
- W2308801214 cites W2086739233 @default.
- W2308801214 cites W2087056550 @default.
- W2308801214 cites W2091279754 @default.
- W2308801214 cites W2093606206 @default.
- W2308801214 cites W2096783891 @default.
- W2308801214 cites W2097289125 @default.
- W2308801214 cites W2098474039 @default.
- W2308801214 cites W2101731216 @default.
- W2308801214 cites W2102773855 @default.
- W2308801214 cites W2104384770 @default.
- W2308801214 cites W2104400024 @default.
- W2308801214 cites W2105214585 @default.
- W2308801214 cites W2111582716 @default.
- W2308801214 cites W2113973815 @default.
- W2308801214 cites W2114070092 @default.
- W2308801214 cites W2114766453 @default.
- W2308801214 cites W2115520939 @default.
- W2308801214 cites W2115759508 @default.
- W2308801214 cites W2115819181 @default.
- W2308801214 cites W2119390857 @default.
- W2308801214 cites W2121996896 @default.
- W2308801214 cites W2122107066 @default.
- W2308801214 cites W2123490990 @default.
- W2308801214 cites W2124036670 @default.
- W2308801214 cites W2124210271 @default.
- W2308801214 cites W2124941470 @default.
- W2308801214 cites W2131212168 @default.
- W2308801214 cites W2134114724 @default.
- W2308801214 cites W2134924469 @default.
- W2308801214 cites W2144216698 @default.
- W2308801214 cites W2145932909 @default.
- W2308801214 cites W2146892790 @default.
- W2308801214 cites W2152369882 @default.
- W2308801214 cites W2153495666 @default.
- W2308801214 cites W2154422767 @default.
- W2308801214 cites W2156847772 @default.