Matches in SemOpenAlex for { <https://semopenalex.org/work/W2308904057> ?p ?o ?g. }
- W2308904057 endingPage "3009" @default.
- W2308904057 startingPage "3000" @default.
- W2308904057 abstract "We asked whether episodic-like memory requires neural mechanisms independent of those that mediate its component memories for what, when, and where, and if neuronal connectivity between the medial prefrontal cortex (mPFC) and the hippocampus (HPC) CA3 subregion is essential for episodic-like memory. Unilateral lesion of the mPFC was combined with unilateral lesion of the CA3 in the ipsi- or contralateral hemispheres in rats. Episodic-like memory was tested using a task, which assesses the integration of memories for what, where, and when concomitantly. Tests for novel object recognition (what), object place (where), and temporal order memory (when) were also applied. Bilateral disconnection of the mPFC-CA3 circuit by N-methyl-d-aspartate (NMDA) lesions disrupted episodic-like memory, but left the component memories for object, place, and temporal order, per se, intact. Furthermore, unilateral NMDA lesion of the CA3 plus injection of (6-cyano-7-nitroquinoxaline-2,3-dione) (CNQX) (AMPA/kainate receptor antagonist), but not AP-5 (NMDA receptor antagonist), into the contralateral mPFC also disrupted episodic-like memory, indicating the mPFC AMPA/kainate receptors as critical for this circuit. These results argue for a selective neural system that specifically subserves episodic memory, as it is not critically involved in the control of its component memories for object, place, and time." @default.
- W2308904057 created "2016-06-24" @default.
- W2308904057 creator A5008574324 @default.
- W2308904057 creator A5016205101 @default.
- W2308904057 creator A5061940282 @default.
- W2308904057 creator A5071365334 @default.
- W2308904057 creator A5078764409 @default.
- W2308904057 date "2015-06-05" @default.
- W2308904057 modified "2023-09-26" @default.
- W2308904057 title "Evidence for a Specific Integrative Mechanism for Episodic Memory Mediated by AMPA/kainate Receptors in a Circuit Involving Medial Prefrontal Cortex and Hippocampal CA3 Region" @default.
- W2308904057 cites W1606464716 @default.
- W2308904057 cites W1766797326 @default.
- W2308904057 cites W1967531155 @default.
- W2308904057 cites W1973490159 @default.
- W2308904057 cites W1977464534 @default.
- W2308904057 cites W1979253267 @default.
- W2308904057 cites W1980944036 @default.
- W2308904057 cites W1982298223 @default.
- W2308904057 cites W1982567191 @default.
- W2308904057 cites W1985513367 @default.
- W2308904057 cites W1989019473 @default.
- W2308904057 cites W1994142018 @default.
- W2308904057 cites W1996475191 @default.
- W2308904057 cites W1996738274 @default.
- W2308904057 cites W2001711642 @default.
- W2308904057 cites W2009102686 @default.
- W2308904057 cites W2010557264 @default.
- W2308904057 cites W2011566601 @default.
- W2308904057 cites W2015468244 @default.
- W2308904057 cites W2020549903 @default.
- W2308904057 cites W2028978164 @default.
- W2308904057 cites W2029210342 @default.
- W2308904057 cites W2030028969 @default.
- W2308904057 cites W2035346633 @default.
- W2308904057 cites W2035523884 @default.
- W2308904057 cites W2036773579 @default.
- W2308904057 cites W2038809411 @default.
- W2308904057 cites W2039736626 @default.
- W2308904057 cites W2041457323 @default.
- W2308904057 cites W2042522288 @default.
- W2308904057 cites W2049038171 @default.
- W2308904057 cites W2049191904 @default.
- W2308904057 cites W2059215368 @default.
- W2308904057 cites W2068395896 @default.
- W2308904057 cites W2072441360 @default.
- W2308904057 cites W2073778714 @default.
- W2308904057 cites W2074887182 @default.
- W2308904057 cites W2075949847 @default.
- W2308904057 cites W2076133795 @default.
- W2308904057 cites W2081980063 @default.
- W2308904057 cites W2084391069 @default.
- W2308904057 cites W2084629122 @default.
- W2308904057 cites W2086967399 @default.
- W2308904057 cites W2089059900 @default.
- W2308904057 cites W2095056606 @default.
- W2308904057 cites W2095882961 @default.
- W2308904057 cites W2098430271 @default.
- W2308904057 cites W2098807436 @default.
- W2308904057 cites W2100985468 @default.
- W2308904057 cites W2102411019 @default.
- W2308904057 cites W2114302768 @default.
- W2308904057 cites W2120708979 @default.
- W2308904057 cites W2121711857 @default.
- W2308904057 cites W2123296304 @default.
- W2308904057 cites W2126691904 @default.
- W2308904057 cites W2131979896 @default.
- W2308904057 cites W2135123788 @default.
- W2308904057 cites W2138223008 @default.
- W2308904057 cites W2144531560 @default.
- W2308904057 cites W2147970286 @default.
- W2308904057 cites W2150185446 @default.
- W2308904057 cites W2155096497 @default.
- W2308904057 cites W2156466070 @default.
- W2308904057 cites W2157933061 @default.
- W2308904057 cites W2167775278 @default.
- W2308904057 cites W2346578572 @default.
- W2308904057 cites W2502971911 @default.
- W2308904057 doi "https://doi.org/10.1093/cercor/bhv112" @default.
- W2308904057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26048953" @default.
- W2308904057 hasPublicationYear "2015" @default.
- W2308904057 type Work @default.
- W2308904057 sameAs 2308904057 @default.
- W2308904057 citedByCount "32" @default.
- W2308904057 countsByYear W23089040572015 @default.
- W2308904057 countsByYear W23089040572016 @default.
- W2308904057 countsByYear W23089040572017 @default.
- W2308904057 countsByYear W23089040572018 @default.
- W2308904057 countsByYear W23089040572019 @default.
- W2308904057 countsByYear W23089040572020 @default.
- W2308904057 countsByYear W23089040572021 @default.
- W2308904057 countsByYear W23089040572022 @default.
- W2308904057 countsByYear W23089040572023 @default.
- W2308904057 crossrefType "journal-article" @default.
- W2308904057 hasAuthorship W2308904057A5008574324 @default.
- W2308904057 hasAuthorship W2308904057A5016205101 @default.
- W2308904057 hasAuthorship W2308904057A5061940282 @default.
- W2308904057 hasAuthorship W2308904057A5071365334 @default.
- W2308904057 hasAuthorship W2308904057A5078764409 @default.