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- W2308981608 abstract "KIBRA is a regulator of the Hippo‐yes‐associated protein ( YAP ) pathway, which plays a critical role in tumorigenesis. In the present study, we show that KIBRA is a positive regulator in prostate cancer cell proliferation and motility. We found that KIBRA is transcriptionally upregulated in androgen‐insensitive LNC a PC 4‐2 and LNC aP‐C81 cells compared to parental androgen‐sensitive LNC aP cells. Ectopic expression of KIBRA enhances cell proliferation, migration and invasion in both immortalized and cancerous prostate epithelial cells. Accordingly, knockdown of KIBRA reduces migration, invasion and anchorage‐independent growth in LNC aP‐C4‐2/C81 cells. Moreover, KIBRA expression is induced by androgen signaling and KIBRA is partially required for androgen receptor signaling activation in prostate cancer cells. In line with these findings, we further show that KIBRA is overexpressed in human prostate tumors. Our studies uncover unexpected results and identify KIBRA as a tumor promoter in prostate cancer." @default.
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- W2308981608 date "2016-04-05" @default.
- W2308981608 modified "2023-10-16" @default.
- W2308981608 title "KIBRA promotes prostate cancer cell proliferation and motility" @default.
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- W2308981608 doi "https://doi.org/10.1111/febs.13718" @default.
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