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- W2309076462 endingPage "107" @default.
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- W2309076462 abstract "Antibody drug conjugates (ADCs), a promising class of cancer biopharmaceuticals, combine the specificity of therapeutic antibodies with the pharmacological potency of chemical, cytotoxic drugs. Ever since the first ADCs on the market, a plethora of novel ADC technologies has emerged, covering as diverse aspects as antibody engineering, chemical linker optimization and novel conjugation strategies, together aiming at constantly widening the therapeutic window for ADCs. This review primarily focuses on novel chemical and biotechnological strategies for the site-directed attachment of drugs that are currently validated for 2nd generation ADCs to promote conjugate homogeneity and overall stability." @default.
- W2309076462 created "2016-06-24" @default.
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- W2309076462 date "2016-03-22" @default.
- W2309076462 modified "2023-10-01" @default.
- W2309076462 title "Current Status: Site-Specific Antibody Drug Conjugates" @default.
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- W2309076462 doi "https://doi.org/10.1007/s10875-016-0265-6" @default.
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