FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2309083668> ?p ?o ?g. }

• W2309083668 abstract "Metals including iron are present at high concentrations in amyloid plaques in patients with Alzheimer's disease where they are also thought to be co-factors in generating oxidative stress and modulating amyloid formation. In this study we present data from several Drosophila models of neurodegenerative proteinopathies indicating that the interaction between iron and Aβ is specific and is not seen for other aggregation-prone polypeptides. The interaction with iron is likely important in the dimerisation of Aβ and is mediated by three N-terminal histidines. Transgenic fly lines systematically expressing all combinations of His&gt;Ala substitutions in Aβ were generated and were used to study the pathological role of these residues. Developmental eye phenotypes, longevity and histological examinations indicate that the N-terminal histidines have distinct position-dependent and -independent mechanisms. The former mediate the toxic effects of metals and Aβ aggregation under non-oxidising conditions and the latter are relevant under oxidising conditions. Understanding how Aβ mediates neurotoxic effects in vivo will help us better target pathological pathways using aggregation-blockers and metal-modifying agents." @default.
• W2309083668 created "2016-06-24" @default.
• W2309083668 creator A5012123270 @default.
• W2309083668 creator A5045465592 @default.
• W2309083668 creator A5082766822 @default.
• W2309083668 date "2015-01-01" @default.
• W2309083668 modified "2023-09-26" @default.
• W2309083668 title "Iron is a specific cofactor for distinct oxidation- and aggregation-dependent Aβ toxicity mechanisms" @default.
• W2309083668 cites W1430904820 @default.
• W2309083668 cites W1495293294 @default.
• W2309083668 cites W1499828206 @default.
• W2309083668 cites W1522735924 @default.
• W2309083668 cites W1593949795 @default.
• W2309083668 cites W1619082318 @default.
• W2309083668 cites W1643390591 @default.
• W2309083668 cites W1659080107 @default.
• W2309083668 cites W1672072946 @default.
• W2309083668 cites W1731253253 @default.
• W2309083668 cites W1797763128 @default.
• W2309083668 cites W1966833359 @default.
• W2309083668 cites W1967922486 @default.
• W2309083668 cites W1970496814 @default.
• W2309083668 cites W1972850054 @default.
• W2309083668 cites W1978918572 @default.
• W2309083668 cites W1980906872 @default.
• W2309083668 cites W1983789627 @default.
• W2309083668 cites W1986384924 @default.
• W2309083668 cites W1986646115 @default.
• W2309083668 cites W1991970246 @default.
• W2309083668 cites W1996579240 @default.
• W2309083668 cites W1997703490 @default.
• W2309083668 cites W2000654975 @default.
• W2309083668 cites W2002017682 @default.
• W2309083668 cites W2003231344 @default.
• W2309083668 cites W2008362268 @default.
• W2309083668 cites W2009252276 @default.
• W2309083668 cites W2018333394 @default.
• W2309083668 cites W2021989110 @default.
• W2309083668 cites W2022452013 @default.
• W2309083668 cites W2027839322 @default.
• W2309083668 cites W2029216084 @default.
• W2309083668 cites W2032881767 @default.
• W2309083668 cites W2033796407 @default.
• W2309083668 cites W2037160815 @default.
• W2309083668 cites W2037358762 @default.
• W2309083668 cites W2038120434 @default.
• W2309083668 cites W2039161703 @default.
• W2309083668 cites W2040042236 @default.
• W2309083668 cites W2040545684 @default.
• W2309083668 cites W2041956586 @default.
• W2309083668 cites W2042103517 @default.
• W2309083668 cites W2042398156 @default.
• W2309083668 cites W2045153164 @default.
• W2309083668 cites W2045262404 @default.
• W2309083668 cites W2046209489 @default.
• W2309083668 cites W2046771932 @default.
• W2309083668 cites W2046997729 @default.
• W2309083668 cites W2051516838 @default.
• W2309083668 cites W2051807096 @default.
• W2309083668 cites W2052112605 @default.
• W2309083668 cites W2054698767 @default.
• W2309083668 cites W2058723245 @default.
• W2309083668 cites W2060215277 @default.
• W2309083668 cites W2064770792 @default.
• W2309083668 cites W2066193360 @default.
• W2309083668 cites W2068609215 @default.
• W2309083668 cites W2073073462 @default.
• W2309083668 cites W2074726646 @default.
• W2309083668 cites W2076162696 @default.
• W2309083668 cites W2080670841 @default.
• W2309083668 cites W2082429191 @default.
• W2309083668 cites W2083500052 @default.
• W2309083668 cites W2083633251 @default.
• W2309083668 cites W2086441058 @default.
• W2309083668 cites W2092242754 @default.
• W2309083668 cites W2093861673 @default.
• W2309083668 cites W2095898664 @default.
• W2309083668 cites W2096386031 @default.
• W2309083668 cites W2096410114 @default.
• W2309083668 cites W2097753140 @default.
• W2309083668 cites W2106107571 @default.
• W2309083668 cites W2113890085 @default.
• W2309083668 cites W2114139136 @default.
• W2309083668 cites W2114346543 @default.
• W2309083668 cites W2117726740 @default.
• W2309083668 cites W2123913108 @default.
• W2309083668 cites W2124720056 @default.
• W2309083668 cites W2129412868 @default.
• W2309083668 cites W2130196517 @default.
• W2309083668 cites W2131633241 @default.
• W2309083668 cites W2133324295 @default.
• W2309083668 cites W2134889734 @default.
• W2309083668 cites W2135607950 @default.
• W2309083668 cites W2137140827 @default.
• W2309083668 cites W2145629698 @default.
• W2309083668 cites W2150523249 @default.
• W2309083668 cites W2151009423 @default.
• W2309083668 cites W2154755614 @default.
• W2309083668 cites W2154945114 @default.
• W2309083668 cites W2156193029 @default.

• next