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• W2309182806 abstract "Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies for targeting tumors with the toxicity induced by photosensitizers after exposure to near infrared (NIR) light. Herein we compare two NIR-light sources; light emitting diodes (LEDs) and Lasers, for their effectiveness in NIR-PIT. A photosensitizer, IRDye-700DX, conjugated to panitumumab (pan-IR700), was incubated with EGFR-expressing A431 and MDA-MB-468-luc cells. NIR-light was provided by LEDs or Lasers at the same light dose. Laser-light produced more cytotoxicity and greater reductions in IR700-fluorescence intensity than LED-light. Laser-light also produced more cytotoxicity in vivo in both cell lines. Assessment of super-enhanced permeability and retention (SUPR) effects were stronger with Laser than LED. These results suggest that Laser-light produced significantly more cytotoxic effects compared to LEDs. Although LED is less expensive, Laser-light produces superior results in NIR-PIT." @default.
• W2309182806 created "2016-06-24" @default.
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• W2309182806 date "2016-02-13" @default.
• W2309182806 modified "2023-10-10" @default.
• W2309182806 title "Comparative effectiveness of light emitting diodes (LEDs) and Lasers in near infrared photoimmunotherapy" @default.
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• W2309182806 doi "https://doi.org/10.18632/oncotarget.7365" @default.
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